199656-43-4

Basic information

• Product Name: 3-(2-bromo-phenyl)-6-fluoro-2-methyl-3H-quinazolin-4-one
• Synonyms: 3-(2-bromo-phenyl)-6-fluoro-2-methyl-3H-quinazolin-4-one
• CAS NO: 199656-43-4
• Molecular Weight: 333.16
• Mol File: 199656-43-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(2-bromo-phenyl)-6-fluoro-2-methyl-3H-quinazolin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-bromo-phenyl)-6-fluoro-2-methyl-3H-quinazolin-4-one(199656-43-4)
• EPA Substance Registry System: 3-(2-bromo-phenyl)-6-fluoro-2-methyl-3H-quinazolin-4-one(199656-43-4)

Safety Data

• Hazardous Substances Data: 199656-43-4(Hazardous Substances Data)

Upstream product

• 446-08-2 2-amino-5-fluorobenzoic acid 
• 38520-78-4 6-fluoro-2-methyl-4H-benzo[d][1,3]oxazin-4-one 
• 615-36-1 2-bromoaniline 

Relevant articles and documents

Atropisomeric quinazolin-4-one derivatives are potent noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists

Piriqualone (1) was found to be an antagonist of AMPA receptors. Structure-activity optimization was conducted on each of the three rings in 1 to afford a series of potent and selective antagonists. The sterically crowded environment surrounding the N-3 aryl group provided sufficient thermal stability for atropisomers to be isolated. Separation of these atropisomers resulted in the identification of (+)-38 (CP-465,022), a compound that binds to the AMPA receptor with high affinity (IC50 = 36 nM) and displays potent anticonvulsant activity.