199658-92-9

Basic information

• Product Name: 1-(5-Bromo-1H-indol-3-yl)-2-(pyrrolidin-1-yl)ethane-1,2-dione
• Synonyms: 1-(5-Bromo-1H-indol-3-yl)-2-(pyrrolidin-1-yl)ethane-1,2-dione
• CAS NO: 199658-92-9
• Molecular Formula: C₁₄H₁₃BrN₂O₂
• Molecular Weight: 321.173
• Mol File: 199658-92-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 497.4°C at 760 mmHg
• Flash Point: 254.6°C
• Appearance: /
• Density: 1.613g/cm³
• Vapor Pressure: 4.97E-10mmHg at 25°C
• Refractive Index: 1.69
• CAS DataBase Reference: 1-(5-Bromo-1H-indol-3-yl)-2-(pyrrolidin-1-yl)ethane-1,2-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-Bromo-1H-indol-3-yl)-2-(pyrrolidin-1-yl)ethane-1,2-dione(199658-92-9)
• EPA Substance Registry System: 1-(5-Bromo-1H-indol-3-yl)-2-(pyrrolidin-1-yl)ethane-1,2-dione(199658-92-9)

Safety Data

• Hazardous Substances Data: 199658-92-9(Hazardous Substances Data)

Usage

Type of Compound

Synthetic small molecule

Target

Vascular endothelial growth factor receptor (VEGFR)

Mechanism of Action

Inhibition of VEGFR activity

Potential Therapeutic Applications

Treatment of angiogenesis-dependent diseases

Angiogenesis-Dependent Diseases

Cancer, certain eye disorders

Additional Effects

Inhibition of cancer cell growth and proliferation

Current Status

Research on pharmacological properties and clinical applications is ongoing

InChI:InChI=1/C14H13BrN2O2/c15-9-3-4-12-10(7-9)11(8-16-12)13(18)14(19)17-5-1-2-6-17/h3-4,7-8,16H,1-2,5-6H2

Upstream product

• 123-75-1 pyrrolidine 
• 63843-81-2 2-(5-bromo-1H-indol-3-yl)-2-oxoacetyl chloride 
• 10075-50-0 5-bromo-1H-indole 

Downstream Products

• 17274-68-9 5-bromo-3-(2-(pyrrolidin-1-yl)ethyl)-1H-indole 
• 208464-62-4 5-(1-aza-1-benzylcyclohex-3-en-4-yl)-3-(2-pyrrolidinylethyl)-1H-indole 
• 208464-44-2 5-bromo-3-(2-pyrrolidinylethyl)-1-benzoylindole 
• 208464-69-1 5-Cyclohexyl-3-(2-pyrrolidinylethyl)-1H-indole 
• 208464-61-3 5-(cyclohex-1-en-1-yl)-3-(2-pyrrolidinylethyl)-1H-indole 
• 208464-52-2 5-(1-hydroxycyclohex-1-yl)-3-(2-pyrrolidinylethyl)-1H-indole 
• 208464-79-3 C₂₆H₂₈N₂O₂ 

Relevant articles and documents

5-Thienyltryptamine derivatives as serotonin 5-HT(1B/1D) receptor agonists: Potential treatments for migraine

A series of 5-(2- or 3-thienyl)tryptamine derivatives (9) has been synthesized and shown to be potent and selective 5-HT(1D) versus 5-HT(1B) receptor agonists and, therefore, potential treatments for migraine. (C) 2000 Elsevier Science Ltd. All rights reserved.

3-(2-Pyrrolidin-1-ylethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity human 5-HT1B/1D ligands

A series of 3-(2-pyrrolidin-1-ylethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)- 1H-indole derivatives (2) has been prepared using parallel synthesis techniques, and their structure-activity relationships studied. High affinity human 5-HT1B/1D (h5-HT1B/1D) ligands have been identified.