199739-10-1 Usage
Description
Paliperidone Palmitate [USAN], an atypical long-acting antipsychotic, is designed for the treatment of schizophrenia. It offers a fast onset during the acute phase and provides continuous improvement of symptoms in the maintenance phase. With solid efficacy and convenient administration, Paliperidone Palmitate presents a new option for schizophrenia treatment, aiding patients in adhering to the treatment regimen and preventing relapse.
Uses
Used in Pharmaceutical Industry:
Paliperidone Palmitate [USAN] is used as a long-acting injectable atypical antipsychotic for the treatment of schizophrenia. Its administration method allows for monthly injections, which was approved by the CFDA in 2011, and is indicated for both acute and maintenance treatment of the condition. This long-acting formulation helps patients adhere to their treatment plan, reducing the risk of relapse and improving overall management of schizophrenia.
Side effects
The review of the literature also underlined that paliperidone palmitate
is well tolerated, compared with placebo. Frequency and severity of
side-effects such as extrapyramidal symptoms, hyperprolactinemia and
weight gain, was similar or less than those found in treatment with
other atypical antipsychotics, including long-acting ones.
Check Digit Verification of cas no
The CAS Registry Mumber 199739-10-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,9,7,3 and 9 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 199739-10:
(8*1)+(7*9)+(6*9)+(5*7)+(4*3)+(3*9)+(2*1)+(1*0)=201
201 % 10 = 1
So 199739-10-1 is a valid CAS Registry Number.
199739-10-1Relevant articles and documents
Synthesis process of paliperidone palmitate
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Paragraph 0036; 0046-0051; 0061-0066; 0076-0080, (2019/10/04)
Belonging to the technical field of pharmaceutical compositions, the invention relates to a synthesis process of paliperidone palmitate. Through synthesis of P (paliperidone), refinement of P synthesis of PP (paliperidone palmitate) and refinement of PP, the paliperidone palmitate can be prepared. According to the invention, the process is controllable, the cost is low, the impurities are controllable, the refining process is simple and convenient, the product purity is high, and the yield is high.
PREPARATION OF 3-[2-[4-((6-FLUORO-1, 2-BENZISOXAZOL-3-YL)-L-PIPERIDINYL)-6, 7, 8, 9-TETRAHYDRO-9-HYDROXY-2-METHYL-4H-PYRIDO[ 1, 2-A]-PYRIMIDIN-4-ONE (PALIPERIDONE) AND PALIPERIDONE PALMITATE.
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Page/Page column 11-12, (2013/02/28)
Provided is a process for the synthesis of 3-[2-[4-((6-fluoro-1,2-benzisoxazol-3-y l)-1-piperidinyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]-pyrimidin -4-one (Paliperidone) and Paliperidone Palmitate through a novel intermediate 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidin -4-one palmitate ester. A process for preparing a compound of formula VIII through a compound of formula VII is also provide.