199928-04-6

Basic information

• Product Name: 4-(4-Ethoxycarbonyl-3-oxo-butyl)-benzoic acid methyl ester
• Synonyms: 4-(4-Ethoxycarbonyl-3-oxo-butyl)-benzoic acid methyl ester
• CAS NO: 199928-04-6
• Molecular Weight: 278.305
• Mol File: 199928-04-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-Ethoxycarbonyl-3-oxo-butyl)-benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Ethoxycarbonyl-3-oxo-butyl)-benzoic acid methyl ester(199928-04-6)
• EPA Substance Registry System: 4-(4-Ethoxycarbonyl-3-oxo-butyl)-benzoic acid methyl ester(199928-04-6)

Safety Data

• Hazardous Substances Data: 199928-04-6(Hazardous Substances Data)

Upstream product

• 18457-03-9 Ethyl trimethylsilyl malonate 
• 151937-09-6 3-(4-methoxycarbonylphenyl)propanoic acid 

Downstream Products

• 199928-01-3 (S)-2-{4-[2-(2,4-Diamino-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester 
• 199928-09-1 (S)-2-{4-[2-(2-Amino-4,7-dioxo-3,4,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester 
• 199928-08-0 (S)-2-[4-(4-Ethoxycarbonyl-3-oxo-butyl)-benzoylamino]-pentanedioic acid dimethyl ester 
• 199928-07-9 4-(4-Ethoxycarbonyl-3-oxo-butyl)-benzoic acid 
• 199928-05-7 4-[2-(2-Amino-4,7-dioxo-3,4,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-5-yl)-ethyl]-benzoic acid methyl ester 

Relevant articles and documents

Synthesis of a pyrido[2,3-d]pyrimidine analogue of the multitargeted antifolate LY231514

Syntheses of pyrido[2,3-d]pyrimidines (9) and (21), ring-expanded analogues of the antitumor agent LY231514 (7), and its 4-amino analog, respectively, are described. Preliminary in vitro cell culture evaluation has shown that expansion of the pyrrole ring of the latter two pyrrolo[2,3-d]pyrimidines through introduction of a carbonyl group between positions 6 and 7 results in complete loss of cell growth inhibitory activity.