200006-08-2 Usage
Description
(+/-)-NFPS HYDROCHLORIDE, also known as ALX 5407 Hydrochloride, is a chemical compound with potential applications in the pharmaceutical industry. It is used in the preparation of amino acid derivatives and has been studied for its effects on neurological and neuropsychiatric disorders.
Uses
Used in Pharmaceutical Industry:
(+/-)-NFPS HYDROCHLORIDE is used as a precursor for the preparation of amino acid derivatives, which are essential in the treatment of neurological and neuropsychiatric disorders. Its role in this application is to provide a foundation for the development of new pharmaceuticals that can address various mental health conditions.
Used in Neurological Research:
(+/-)-NFPS HYDROCHLORIDE is used as a glycine transporter (GlyT1) inhibitor to study its effects on inhibitory postsynaptic current and N-methyl-D-aspartate receptor (NMDA)-mediated excitatory postsynaptic currents (EPSCs). This application helps researchers understand the underlying mechanisms of neurological disorders and develop targeted treatments.
Used in Neuropsychiatric Research:
(+/-)-NFPS HYDROCHLORIDE is used as a GlyT1 inhibitor in the treatment of developmentally diminished NMDA receptor (Grin1D481N) mice to test its effect on the glycine site function. This application aids in the investigation of the compound's potential therapeutic effects on neuropsychiatric disorders and the role of glycine transporters in these conditions.
Biochem/physiol Actions
ALX-5407 hydrochloride (NFPS hydrochloride) is a selective irreversible inhibitor of the glycine transporter GlyT1 with IC50 values of 3 nM for GlyT1 compared to 100 μM for GlyT2. ALX-5407 hydrochloride showed no activity at the inhibitory glycine receptor or glycine site of the NMDA receptor (IC50 > 100 mM).
references
[1]. atkinson bn, bell sc, de vivo m, et al. alx 5407: a potent, selective inhibitor of the hglyt1 glycine transporter. mol pharmacol, 2001, 60(6):1414-20.
Check Digit Verification of cas no
The CAS Registry Mumber 200006-08-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,0,0,0 and 6 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 200006-08:
(8*2)+(7*0)+(6*0)+(5*0)+(4*0)+(3*6)+(2*0)+(1*8)=42
42 % 10 = 2
So 200006-08-2 is a valid CAS Registry Number.