20004-62-0 Usage
Description
Resistomycin is a tetrahydroxyantrone compound that has been isolated and reported to possess a wide range of biological activities. It is known for its effectiveness against various bacteria, including mycobacteria, and viruses. Additionally, Resistomycin has the ability to induce apoptosis and inhibit RNA polymerase, making it a versatile and potent substance in the field of medicine.
Uses
Used in Pharmaceutical Industry:
RESISTOMYCIN is used as an antibiotic for its broad-spectrum activity against bacteria, including mycobacteria, and viruses. Its ability to induce apoptosis and inhibit RNA polymerase contributes to its effectiveness in combating infections and diseases.
Used in Anticancer Applications:
RESISTOMYCIN is used as an apoptosis inducer for its potential role in cancer treatment. By promoting apoptosis, Resistomycin can help in the destruction of cancerous cells and the inhibition of tumor growth.
Used in Research and Development:
RESISTOMYCIN is used as a research compound for studying its various biological activities and potential applications in medicine. Its unique properties make it an interesting subject for further investigation and development of new therapeutic strategies.
Biological Activity
resistomycin is a natural antibiotic.resistomycin is a natural antibiotic produced by several actinobacteriae, such as streptomyces.
in vitro
resistomycin, a tetrahydroxyanthrone derivative, was isolated from the culture broth of streptomyces sulphureus and a similar polyphenolic dianthraquinone, hypericin, was isolated from an extract of hypericum perforatum l. as modulators for apoptosis. in human megakaryoblastic leukemia cmk-7 cells, resistomycin could inhibit apoptosis induced by actinomycin d (ad) with or without acceleration by colcemid (cl), ic50 for inhibition against ad-induced apoptosis was about 0.5 μm and ic50 for inhibition against ad plus cl-induced apoptosis was about 1 μm. cl alone induced weak apoptosis in cells, which could be enhanced by resistomycin. moreover, it was found that both hypericin and resistomycin were able to scavenge superoxide anion radicals at the same rate as luteolin. in addition, pkc in cmk-7 cells could be inhibited by hypericin and luteolin, but not obviously inhibited by resistomycin [1].
references
[1] shiono, y. ,shiono, n.,seo, s., et al. effects of polyphenolic anthrone derivatives, resistomycin and hypercin, on apoptosis in human megakaryoblastic leukemia cmk-7 cell line. z. naturforsch. c. 57(9-10), 923-929 (2002).
Check Digit Verification of cas no
The CAS Registry Mumber 20004-62-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,0,0 and 4 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 20004-62:
(7*2)+(6*0)+(5*0)+(4*0)+(3*4)+(2*6)+(1*2)=40
40 % 10 = 0
So 20004-62-0 is a valid CAS Registry Number.
