200335-35-9

Basic information

• Product Name: Phenyl-carbamic acid (4aR,6S,7R,7aS)-2-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-3-isopropyl-6-methoxy-hexahydro-furo[2,3-e][1,3,2]oxazaphosphinin-7-yl ester
• CAS NO: 200335-35-9
• Molecular Weight: 708.821
• Mol File: 200335-35-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Phenyl-carbamic acid (4aR,6S,7R,7aS)-2-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-3-isopropyl-6-methoxy-hexahydro-furo[2,3-e][1,3,2]oxazaphosphinin-7-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phenyl-carbamic acid (4aR,6S,7R,7aS)-2-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-3-isopropyl-6-methoxy-hexahydro-furo[2,3-e][1,3,2]oxazaphosphinin-7-yl ester(200335-35-9)
• EPA Substance Registry System: Phenyl-carbamic acid (4aR,6S,7R,7aS)-2-[(2R,3S,5R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-3-isopropyl-6-methoxy-hexahydro-furo[2,3-e][1,3,2]oxazaphosphinin-7-yl ester(200335-35-9)

Safety Data

• Hazardous Substances Data: 200335-35-9(Hazardous Substances Data)

Upstream product

• 6893-65-8 1,2-di-O-isopropylidene-5-O-tosyl-D-xylofuranose 
• 200335-31-5 ((2R,3R,4R,5S)-3-Benzyloxy-4-hydroxy-5-methoxy-tetrahydro-furan-2-ylmethyl)-isopropyl-carbamic acid benzyl ester 
• 200335-34-8 Phenyl-carbamic acid (2S,3R,4S,5R)-4-hydroxy-5-(isopropylamino-methyl)-2-methoxy-tetrahydro-furan-3-yl ester 
• 200335-30-4 ((3aR,5R,6S,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethyl)-isopropyl-carbamic acid benzyl ester 
• 200335-29-1 3-O-benzyl-5-deoxy-5-isopropylamino-1,2-O-isopropylidenexylofuranose 
• 187342-10-5 5-deoxy-5-isopropylamino-1,2-O-isopropylidene-α-D-xylofuranose 
• 40733-28-6 5'-tert-butyldimethylsilyloxy-2'-deoxythymidine 
• 200335-33-7 Phenyl-carbamic acid (2S,3R,4S,5R)-4-benzyloxy-5-[(benzyloxycarbonyl-isopropyl-amino)-methyl]-2-methoxy-tetrahydro-furan-3-yl ester 

Relevant articles and documents

Oxazaphosphorinane precursors to the diastereoselective synthesis of DNA phosphorothioates

New chiral oxazaphosphorinanes were synthesized as potential precursors to chiral phosphite triesters. Oxazaphosphorinanes 10 and 14 derived from cholesterol and camphor respectively were obtained as stable compounds. They led to rearrangement products in the acidic conditions required for coupling. Then, oxazaphosphorinane 22 derived from D-xylose was synthesized, and led to the diastereoselective synthesis of a T-T phosphorothioate dimer in a 28.5:1 (Rp)/(Sp) ratio.