200335-40-6

Basic information

• Product Name: FMOC-L-ISOASPARAGINE
• Synonyms: N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-ASPARTIC ACID ALPHA-AMIDE;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-ISOASPARAGINE;FMOC-L-ISOASPARAGINE;FMOC-L-ASPARTIC ACID ALPHA-AMIDE;FMOC-ISOASN-OH;FMOC-ASP-NH2;FMOC-ASPARTIC ACID-NH2;FMoc-Isoasn-OH, FMoc-L-isoasparagine
• CAS NO: 200335-40-6
• Molecular Formula: C19H18N2O5
• Molecular Weight: 354.36
• Mol File: 200335-40-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 662.1 °C at 760 mmHg
• Flash Point: 354.2 °C
• Appearance: /
• Density: 1.362 g/cm³
• Vapor Pressure: 1.97E-18mmHg at 25°C
• Refractive Index: 1.626
• Storage Temp.: 2-8°C
• CAS DataBase Reference: FMOC-L-ISOASPARAGINE(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-L-ISOASPARAGINE(200335-40-6)
• EPA Substance Registry System: FMOC-L-ISOASPARAGINE(200335-40-6)

Safety Data

• WGK Germany: 3
• F: 10
• Hazardous Substances Data: 200335-40-6(Hazardous Substances Data)

Usage

Description

FMOC-L-ISOASPARAGINE, also known as Fmoc-Asp-NH2, is a synthetic compound that is a derivative of the naturally occurring amino acid L-isoaspartic acid. It is characterized by the presence of a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group, which is commonly used in peptide synthesis to protect the amino group of amino acids. FMOC-L-ISOASPARAGINE is a white crystalline powder and is used in various applications across different industries.

Uses

Used in Pharmaceutical Industry:
FMOC-L-ISOASPARAGINE is used as a reactant in the preparation of NK3-receptor agonists, which are compounds that stimulate the activity of the NK3 receptor. These agonists are particularly useful in the treatment of conditions characterized by deficient secretion of tachykinins, a family of neuropeptides involved in various physiological processes, including pain transmission, inflammation, and neuroendocrine regulation.
Used in Peptide Synthesis:
FMOC-L-ISOASPARAGINE is used as a building block in the synthesis of peptides and proteins. The Fmoc protecting group allows for the selective protection of the amino group during the synthesis process, enabling the stepwise assembly of peptide chains. This selective protection is crucial for the successful synthesis of complex peptides and proteins with specific sequences and functions.
Used in Research and Development:
FMOC-L-ISOASPARAGINE is used as a research tool in the study of protein structure, function, and interactions. Its unique chemical properties and the presence of the Fmoc protecting group make it a valuable compound for investigating the role of L-isoaspartic acid in various biological processes and for developing new therapeutic agents targeting specific protein-protein interactions.

InChI:InChI=1/C19H18N2O5/c20-18(24)16(9-17(22)23)21-19(25)26-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15/h1-8,15-16H,9-10H2,(H2,20,24)(H,21,25)(H,22,23)/t16-/m0/s1