2006-80-6

Basic information

• Product Name: methyl 2-(2-methyl-4-oxoquinazolin-3(4H)-yl)benzoate
• Synonyms: 2-(2-Methyl-4-oxo-4H-quinazolin-3-yl)-benzoic acid methyl ester; 2-(2-methyl-4-oxo-4H-quinazoline-3-yl)benzoic acid methyl ester
• CAS NO: 2006-80-6
• Molecular Formula: C₁₇H₁₄N₂O₃
• Molecular Weight: 294.3047
• Mol File: 2006-80-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 465.4°C at 760 mmHg
• Flash Point: 235.3°C
• Density: 1.24g/cm³
• Vapor Pressure: 7.69E-09mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: methyl 2-(2-methyl-4-oxoquinazolin-3(4H)-yl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(2-methyl-4-oxoquinazolin-3(4H)-yl)benzoate(2006-80-6)
• EPA Substance Registry System: methyl 2-(2-methyl-4-oxoquinazolin-3(4H)-yl)benzoate(2006-80-6)

Safety Data

• Hazardous Substances Data: 2006-80-6(Hazardous Substances Data)

Upstream product

• 134-20-3 2-carbomethoxyaniline 
• 89-52-1 o-acetylamino-benzoic acid 
• 96999-04-1 methyl N-(2-carbomethoxyphenyl)acetimidate 
• 31499-90-8 2,1-benzisoxazol-3(1H)-one 
• 64-17-5 ethanol 
• 49854-16-2 methyl 2-(2-aminobenzoylamino)benzoate 
• 64001-48-5 2-(sulfinylamino)benzoyl chloride 
• 118-92-3 anthranilic acid 
• 72367-10-3 2-(2-nitrobenzoylamino)benzoic acid methyl ester 
• 552-16-9 ortho-nitrobenzoic acid 
• 610-14-0 2-nitrobenzyl chloride 
• 2719-08-6 methyl 2-(acetylamino)benzoate 

Downstream Products

• 4005-06-5 2-(2-methyl-4-oxo-4H-quinazolin-3-yl)-benzoic acid 
• 61554-52-7 2-(2-bromomethyl-4-oxo-4H-quinazolin-3-yl)-benzoic acid methyl ester 

Relevant articles and documents

Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph3P-I2

Readily available N-substituted amides or their requisite carboxylic acids or acid chlorides have been used to construct 2,3-disubstituted-3H-quinazolin-4-ones in a one-pot procedure. Key transformation in this convergent approach involves Ph3P-I2-mediated formation of amidine upon condensation of an amide or the intermediate amide with methyl anthranilate. Cyclization of the amidine-tethered anthranilate then affords 2,3-disubstituted-3H-quinazolin-4-ones in good to excellent yields under mild conditions.

Efficient syntheses of 2,3-disubstituted natural quinazolinones via iridium catalysis

Natural products sclerotigenin, pegamine, deoxyvasicinone, mackinazolinone, and rutaecarpine were synthesized. Core quinazolinone structures were constructed via Ir catalysis. The Royal Society of Chemistry 2012.

Potential biologically active agents: VIII. Synthesis of 2 methyl (and styryl) 3 aryl 4 (3H) quinazolones

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