200630-96-2

Basic information

• Product Name: N-(3-Acetylphenyl)-N-ethylacetaMide
• Synonyms: N-(3-Acetylphenyl)-N-ethylacetaMide
• CAS NO: 200630-96-2
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.253
• Product Categories: Aromatics, Miscellaneous Reagents
• Mol File: 200630-96-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: N-(3-Acetylphenyl)-N-ethylacetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-Acetylphenyl)-N-ethylacetaMide(200630-96-2)
• EPA Substance Registry System: N-(3-Acetylphenyl)-N-ethylacetaMide(200630-96-2)

Safety Data

• Hazardous Substances Data: 200630-96-2(Hazardous Substances Data)

Usage

Description

N-(3-Acetylphenyl)-N-ethylacetamide is an organic compound with the molecular structure featuring an amide functional group. It is characterized by its pale yellow solid to oil appearance and is known for its role in the synthesis of specific pharmaceutical compounds.

Uses

Used in Pharmaceutical Industry:
N-(3-Acetylphenyl)-N-ethylacetamide is used as a reactant for the preparation of 5-Oxo-Zaleplon (O870470), which is a metabolite of Zaleplon (Z145000). This application is significant in the development and synthesis of new pharmaceutical compounds, potentially contributing to advancements in the treatment of various medical conditions.

Upstream product

• 7463-31-2 3-Acetamidoacetophenone 
• 75-03-6 ethyl iodide 
• 74-96-4 ethyl bromide 
• 98-86-2 acetophenone 
• 121-89-1 3-Nitroacetophenone 
• 557-20-0 diethylzinc 
• 75-36-5 acetyl chloride 

Downstream Products

• 96605-66-2 N-{3-[3-(dimethylamino)prop-2-enoyl]phenyl}-N-ethylacetamide 
• 1158910-07-6 N-(3-(1-(2-(4-chlorophenoxy)phenylamino)ethyl)phenyl)-N-ethylacetamide 

Relevant articles and documents

Electrophilic Amination with Nitroarenes

An exceptionally general electrophilic amination, which directly transforms commercially available nitroarenes into alkylated aromatic aminoboranes with zinc organyl compounds was developed. The reaction starts with a two-step partial reduction of the nitro group to a nitrenoid, which is used in situ as the electrophilic amination reagent. To facilitate isolation, the resulting air- and moisture-sensitive aminoboranes were reacted with a range of electrophiles. The method not only represents a direct transformation of nitro compounds into electrophilic amination reagents but also provides an elegant alternative to dehydrocoupling methods for the generation of aminoboranes.

2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS

The present invention relates to compounds of Formula: (I), or pharmaceutically acceptable salt thereof, wherein the variables are defined in the description. The compounds act as kinase inhibitors.