20071-00-5 Usage
Description
Angiotensin acetate, also known as [Asn1, Val5]-Angiotensin II, is a renin-angiotensin system (RAS) effector molecule that plays a crucial role in regulating blood pressure and fluid balance in the body. It is primarily expressed in vessel walls, lung, and kidney, and binds to angiotensin II type-1 (AT1R) and angiotensin II type-2 (AT2R) receptors. The gene for Angiotensin II is located on human chromosome 3q24.
Uses
Used in Research Applications:
Angiotensin acetate is used as a research tool for studying the effects of various factors, such as ACTH, serotonin, Angiotensin II, carbachol, and elevated [K+], on catecholamine and serotonin release. This helps in understanding the complex interactions and regulatory mechanisms involved in the renin-angiotensin system.
Used in Hypertension Studies:
Angiotensin acetate is used as an inducer of cyclophilin D (CypD)-dependent mitochondrial vascular superoxide (O2.-) production in hypertension research. This application aids in investigating the role of Angiotensin II in the development and progression of hypertension.
Used in Cellular Stress Research:
Angiotensin acetate is used to increase the homocysteine-induced ER stress-inducible, ubiquitin-like domain member 1 (HERPUD1) protein level in HeLa cells. This application is valuable for studying the cellular response to stress and the role of Angiotensin II in modulating these responses.
Biochem/physiol Actions
Synthetic angiotensin agonist that is involved in the regulation of blood pressure, water consumption, and hydromineral balance in fish.
Check Digit Verification of cas no
The CAS Registry Mumber 20071-00-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,0,7 and 1 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 20071-00:
(7*2)+(6*0)+(5*0)+(4*7)+(3*1)+(2*0)+(1*0)=45
45 % 10 = 5
So 20071-00-5 is a valid CAS Registry Number.
InChI:InChI=1/C49H70N14O11.C2H4O2/c1-26(2)39(61-42(67)33(12-8-18-55-49(52)53)57-41(66)32(50)23-38(51)65)45(70)58-34(20-29-14-16-31(64)17-15-29)43(68)62-40(27(3)4)46(71)59-35(22-30-24-54-25-56-30)47(72)63-19-9-13-37(63)44(69)60-36(48(73)74)21-28-10-6-5-7-11-28;1-2(3)4/h5-7,10-11,14-17,24-27,32-37,39-40,64H,8-9,12-13,18-23,50H2,1-4H3,(H2,51,65)(H,54,56)(H,57,66)(H,58,70)(H,59,71)(H,60,69)(H,61,67)(H,62,68)(H,73,74)(H4,52,53,55);1H3,(H,3,4)/t32-,33-,34-,35-,36-,37-,39-,40-;/m0./s1
