2008-49-3

Basic information

• Product Name: N-(3-chlorophenyl)furan-2-carboxamide
• Synonyms: 2-furancarboxamide, N-(3-chlorophenyl)-; N-(3-Chlorophenyl)-2-furamide
• CAS NO: 2008-49-3
• Molecular Formula: C₁₁H₈ClNO₂
• Molecular Weight: 221.6397
• Mol File: 2008-49-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 247.6°C at 760 mmHg
• Flash Point: 103.5°C
• Density: 1.359g/cm³
• Vapor Pressure: 0.0254mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: N-(3-chlorophenyl)furan-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-chlorophenyl)furan-2-carboxamide(2008-49-3)
• EPA Substance Registry System: N-(3-chlorophenyl)furan-2-carboxamide(2008-49-3)

Safety Data

• Hazardous Substances Data: 2008-49-3(Hazardous Substances Data)

Upstream product

• 527-69-5 2-furancarbonyl chloride 
• 108-42-9 3-chloro-aniline 
• 118486-94-5 2-(tributylstannyl)furan 
• 2909-38-8 m-chlorophenyl isocyanate 
• 1026046-13-8 2-furanoyl sulfonate 
• 88-14-2 2-furanoic acid 

Relevant articles and documents

Determination of aromaticity indices of thiophene and furan by nuclear magnetic resonance spectroscopic analysis of their anilides

A series of m- and p-substituted anilides of benzoic acid, 2-thienoic acid, and 2-furoic acid were prepared and their 1H and 13C nmr spectroscopic characteristics were examined. In general, good correlations were observed between the chemical shifts of proton and carbon signals of the acyl aromatic rings and the Hammett σ. Plots of the chemical shift values of the carbonyl carbons of the benzanilides against those of the 2-thienamides and 2-furamides gave an excellent correlation and the values of the slopes are 0.79 and 0.52, respectively, in dimethyl sulfoxide-d6. The slopes could be considered as a set of aromaticity index.

Facile and Effective Synthesis of Unusually Substituted Aromatic N-Phenylamides

A mild and effective new method for the preparation of a variety of arylamides 3a-i as well as heterocyclic 5a, b and 6 and olefinic amides 7, 9 is described.The reaction of trialkylstannyl-substituted aromatic, heterocyclic or vinylic hydrocarbons with aryl isocyanates in the presence of aluminium trichloride provides the corresponding N-aryl-substituted amides in good to excellent yields.The stannyl group serves as a powerful leaving group superior to hydrogen by several powers of ten which allows, via ipso substitution, to obtain isomer patterns not accessible by normal electrophilic substitution reactions, e. g. substitution in meta position with respect to a methoxy group.