200880-42-8 Usage
Description
1,2-Distearoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt), also known as DSPG, is a phospholipid molecule with a phosphate polar head connected to two non-polar lipid (stearic acid) chains by a glycerol molecule. In water, the molecule can orient itself into a lipid bilayer and can be used for drug encapsulation, such as drug-loaded liposomes or nanoparticles.
Uses
Used in Pharmaceutical Industry:
1,2-Distearoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) is used as a component in the formulation of PEGylated liposomal drugs for targeted drug delivery and enhanced therapeutic efficacy.
1,2-Distearoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) is used as a key ingredient in the preparation of polyethylene glycol-modified liposomal doxorubicin for therapies against drug-resistant tumors, providing an effective treatment option for cancer patients with drug-resistant conditions.
Additionally, 1,2-distearoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) is used in the PEGylated liposomal drug formulation of the anti-cancer agent oxaliplatin, improving the drug's solubility, stability, and bioavailability, while reducing side effects and enhancing overall treatment outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 200880-42-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,0,8,8 and 0 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 200880-42:
(8*2)+(7*0)+(6*0)+(5*8)+(4*8)+(3*0)+(2*4)+(1*2)=98
98 % 10 = 8
So 200880-42-8 is a valid CAS Registry Number.
200880-42-8Relevant articles and documents
Preparation process of distearoyl phosphatidylglycerol sodium
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Paragraph 0038; 0061-0070; 0100-0106, (2021/09/08)
The invention relates to a preparation process of distearoyl phosphatidylglycerol (DSPGNa), wherein the route is centered on the intermediate phosphorus oxygen bond, and the compound is split into butt joint of two segments. The glycerol end is firstly connected to the phosphorus oxygen bond, then the intermediate 7 is connected, and the utilization rate of the intermediate 7 which is relatively expensive is increased as much as possible.