201005-58-5Relevant articles and documents
Anticonvulsant Activity of Enantiomeric N-trans-Cinnamoyl Derivatives of 2-Aminopropan-1-ols and 2-Aminobutan-1-ols
Gunia-Krzyzak, Agnieszka,Zes?awska, Ewa,Nitek, Wojciech,Popió?, Justyna,Marona, Henryk
, p. 482 - 488 (2016/06/08)
Epilepsy, one of the most frequent neurological disorders, is still insufficiently treated in about 30% of patients. As a consequence, identification of novel anticonvulsant agents is an important issue in medicinal chemistry. In the present article we re
Asymmetric hetero-Diels-Alder reactions of alkenyldihydrooxazoles. Synthesis of oxazolo[3,2-c]pyrimidines and related compounds
Elliott, Mark C.,Kruisvvijk, Elbertus
, p. 3157 - 3166 (2007/10/03)
Alkenyldihydrooxazoles undergo a highly diastereoselective formal aza-Diels-Alder reaction with aryl and arenesulfonyl isocyanates to give oxazolo[3,2-c]pyrimidines. Depending on the substitution pattern of the alkenyldihydrooxazole, these compounds may then undergo addition of a second equivalent of the isocyanate to give either tetrahydrooxazoIo[3,2-c]pyrimidine-8-carboxamides or octahydroazeto[2,3-7]oxazolo[3,2c]pyrimidines. The second addition is sensitive to steric and electronic factors, and can be prevented in some cases. The Royal Society of Chemistry 1999.