20103-08-6

Basic information

• Product Name: 2-((1-NAPHTHYLMETHYL)AMINO)ETHANOL
• Synonyms: 2-((1-NAPHTHYLMETHYL)AMINO)ETHANOL
• CAS NO: 20103-08-6
• Molecular Formula: C13H15NO
• Molecular Weight: 201.26
• Mol File: 20103-08-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-((1-NAPHTHYLMETHYL)AMINO)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((1-NAPHTHYLMETHYL)AMINO)ETHANOL(20103-08-6)
• EPA Substance Registry System: 2-((1-NAPHTHYLMETHYL)AMINO)ETHANOL(20103-08-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 20103-08-6(Hazardous Substances Data)

Usage

Derived from

naphthalene

Usage

synthetic intermediate in research and industry

Physical form

white to off-white solid at room temperature

Molecular weight

205.26 g/mol

Potential applications

organic synthesis, pharmaceuticals

Unique features

chemical structure and properties

Utilization

building block for the synthesis of various organic compounds and pharmaceutical products

Versatility

potential applications in various fields of chemistry and industry

Upstream product

• 141-43-5 ethanolamine 
• 86-52-2 1-Chloromethylnaphthalene 
• 856377-97-4 2-{[1-Naphthalen-1-yl-meth-(Z)-ylidene]-amino}-ethanol 
• 66-77-3 1-naphthaldehyde 

Relevant articles and documents

Discovery of phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H- pyrimidin-2-one, an effective antithrombotic agent without associated bleeding and insulin resistance

Structure-based evolution of the original fragment leads resulted in the identification of 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2- methylmorpholin-4-yl]-1H-pyrimidin-2-one, (S)-21, a potent, selective phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor with favourable in vivo antiplatelet effect. Despite its antiplatelet action, (S)-21 did not significantly increase bleeding time in dogs. Additionally, due to its enhanced selectivity over p110α, (S)-21 did not induce any insulin resistance in rats.