201049-37-8

Basic information

• Product Name: epothilone E
• Synonyms: epothilone E;[4S,7R,8S,9S,13R,14S,16S(E)]-13,14-Epoxy-4,8-dihydroxy-5,5,7,9-tetramethyl-16-[2-[2-(hydroxymethyl)thiazol-4-yl]-1-methylvinyl]-1-oxacyclohexadecane-2,6-dione
• CAS NO: 201049-37-8
• Molecular Formula: C26H39NO7S
• Molecular Weight: 509.65536
• Mol File: 201049-37-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: epothilone E(CAS DataBase Reference)
• NIST Chemistry Reference: epothilone E(201049-37-8)
• EPA Substance Registry System: epothilone E(201049-37-8)

Safety Data

• Hazardous Substances Data: 201049-37-8(Hazardous Substances Data)

Usage

Description

Epothilone E is a member of the Epothilones family, which are a novel class of antineoplastic agents characterized by their antitubulin activity. These compounds share a similar mechanism of action with taxanes and are known for their reduced susceptibility to multidrug resistance caused by P-glycoprotein. Epothilone E, in particular, has demonstrated significant antitumor activity against various human cancer cells, including those that are taxane-resistant.

Uses

Used in Anticancer Applications:
Epothilone E is utilized as an anticancer agent, specifically targeting human cancer cells that are resistant to taxane treatments. It modulates the microtubule dynamics and disrupts the normal cell division process, leading to the inhibition of tumor growth and progression. The compound's ability to overcome multidrug resistance makes it a valuable asset in the fight against cancer.
Used in Drug Delivery Systems:
To enhance the efficacy and bioavailability of Epothilone E, researchers have developed novel drug delivery systems. These systems employ various organic and metallic nanoparticles as carriers for the delivery of Epothilone E, aiming to improve its distribution, absorption, and therapeutic outcomes in cancer treatment. By optimizing the delivery of Epothilone E, these systems can potentially increase the compound's effectiveness against cancer cells and reduce side effects.

Upstream product

• 204513-12-2 Desoxyepothilone E 
• 204513-22-4 (3S,1E)-1-iodo-2-methylhexa-1,5-dien-3-ol 
• 204513-16-6 (Z)-(4S,7R,8S,9S,16S)-4,8-Dihydroxy-16-((E)-2-iodo-1-methyl-vinyl)-5,5,7,9-tetramethyl-oxacyclohexadec-13-ene-2,6-dione 
• 204513-24-6 (3S,6R,7S,8S)-3-(tert-Butyl-dimethyl-silanyloxy)-7-hydroxy-4,4,6,8-tetramethyl-5-oxo-tridec-12-enoic acid (S)-1-((E)-2-iodo-1-methyl-vinyl)-but-3-enyl ester 
• 204513-26-8 (Z)-(4S,7R,8S,9S,16S)-4-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-16-((E)-2-iodo-1-methyl-vinyl)-5,5,7,9-tetramethyl-oxacyclohexadec-13-ene-2,6-dione 
• 212321-23-8 (4-((E)-2-((1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12-tetramethyl-5,9-dioxo-4,17-dioxabicyclo[14.1.0]-heptadecan-3-yl)prop-1-en-1-yl)thiazol-2-yl)methyl acetate 
• 152044-53-6 epithilone A 
• 212321-22-7 4-((E)-2-((1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12-tetramethyl-5,9-dioxo-4,17-dioxabicyclo[14.1.0]heptadecan-3-yl)prop-1-en-1-yl)-2-methylthiazole 3-oxide 
• 152044-54-7 epothilone B 

Relevant articles and documents

Characterizing the Epothilone Binding Site on β-Tubulin by Photoaffinity Labeling: Identification of β-Tubulin Peptides TARGSQQY and TSRGSQQY as Targets of an Epothilone Photoprobe for Polymerized Tubulin

Photoaffinity labeling with an epothilone A photoprobe led to the identification of the β-tubulin peptides TARGSQQY and TSRGSQQY as targets of the photoprobe for polymerized tubulin. These peptides represent residues 274-281 in different β-tubulin isotype

Epothilones with modified side chain

Epothilones with a modified side chain and process for the preparation thereof are disclosed.

Total Synthesis of Epothilone E and Analogues with Modified Side Chains through the Stille Coupling Reaction

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