201285-35-0

Basic information

• Product Name: 1-(Cyclohexylmethyl)-N-(3,5-dichloro-1-oxidopyridin-4-yl)-3-methylindole-6-carboxamide
• CAS NO: 201285-35-0
• Molecular Formula: C₂₂H₂₃Cl₂N₃O₂
• Molecular Weight: 432.35351
• Mol File: 201285-35-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(Cyclohexylmethyl)-N-(3,5-dichloro-1-oxidopyridin-4-yl)-3-methylindole-6-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(Cyclohexylmethyl)-N-(3,5-dichloro-1-oxidopyridin-4-yl)-3-methylindole-6-carboxamide(201285-35-0)
• EPA Substance Registry System: 1-(Cyclohexylmethyl)-N-(3,5-dichloro-1-oxidopyridin-4-yl)-3-methylindole-6-carboxamide(201285-35-0)

Safety Data

• Hazardous Substances Data: 201285-35-0(Hazardous Substances Data)

Upstream product

• 91872-02-5 4-amino-3,5-dichloropyridine-N-oxide 
• 201286-68-2 1-Cyclohexylmethyl-3-methyl-1 H-indole-6-carboxylic acid 
• 201286-78-4 methyl 1-cyclohexylmethyl-3-methyl-1 H-indole-6-carboxylate 
• 133831-28-4 methyl 3-formyl-6-indolecarboxylate 
• 184151-49-3 methyl 3-methylindole-6-carboxylate 

Relevant articles and documents

Orally active indole N-oxide PDE4 inhibitors

This communication describes the synthesis and in vitro and in vivo evaluation of a novel potent series of phosphodiesterase type (IV) (PDE4) inhibitors. Several of the compounds presented possess low nanomolar IC50's for PDE4 inhibition and excellent in vivo activity for inhibition of TNF-α levels in LPS challenged mice (mouse endotoxemia model). Emesis studies (dog) and efficacy in a SCW arthritis model for the most potent PDE4 inhibitors are presented.