20143-44-6

Basic information

• Product Name: 2-(4-iodophenoxy)acetyl chloride
• Synonyms: 2-(4-iodophenoxy)acetyl chloride
• CAS NO: 20143-44-6
• Molecular Weight: 296.492
• Mol File: 20143-44-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-iodophenoxy)acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-iodophenoxy)acetyl chloride(20143-44-6)
• EPA Substance Registry System: 2-(4-iodophenoxy)acetyl chloride(20143-44-6)

Safety Data

• Hazardous Substances Data: 20143-44-6(Hazardous Substances Data)

Upstream product

• 1878-94-0 4-iodophenoxyacetic acid 

Downstream Products

• 54504-78-8 (4-iodo-phenoxy)-acetic acid 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-ethyl ester 
• 1353754-23-0 C₁₉H₁₆FN₅O₅ 
• 1353754-21-8 N-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]-2-{4-[6-(trifluoromethyl)pyridin-3-yl]phenoxy}acetamide 
• 1353754-19-4 N-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]-2-{[4'-(trifluoromethoxy)biphenyl-4-yl]oxy}acetamide 
• 1353754-17-2 2-[(4'-fluorobiphenyl-4-yl)oxy]-N-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]acetamide 
• 1353754-15-0 N-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]-2-{[4'-(trifluoromethyl)biphenyl-4-yl]oxy}acetamide 
• 1353754-85-4 2-(4-iodophenoxy)-N-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]acetamide 
• 120244-22-6 3-(4-Fluoro-phenyl)-2-(4-iodo-phenoxymethyl)-3H-quinazolin-4-one 
• 120244-27-1 3-(2-Hydroxy-ethyl)-2-(4-iodo-phenoxymethyl)-3H-quinazolin-4-one 
• 65569-50-8 5-Chloro-N-(2-diethylamino-ethyl)-4-[2-(4-iodo-phenoxy)-acetylamino]-2-methoxy-benzamide 

Relevant articles and documents

Noncovalent Inhibitors of Mosquito Acetylcholinesterase 1 with Resistance-Breaking Potency

Resistance development in insects significantly threatens the important benefits obtained by insecticide usage in vector control of disease-transmitting insects. Discovery of new chemical entities with insecticidal activity is highly desired in order to develop new insecticide candidates. Here, we present the design, synthesis, and biological evaluation of phenoxyacetamide-based inhibitors of the essential enzyme acetylcholinesterase 1 (AChE1). AChE1 is a validated insecticide target to control mosquito vectors of, e.g., malaria, dengue, and Zika virus infections. The inhibitors combine a mosquito versus human AChE selectivity with a high potency also for the resistance-conferring mutation G122S; two properties that have proven challenging to combine in a single compound. Structure-activity relationship analyses and molecular dynamics simulations of inhibitor-protein complexes have provided insights that elucidate the molecular basis for these properties. We also show that the inhibitors demonstrate in vivo insecticidal activity on disease-transmitting mosquitoes. Our findings support the concept of noncovalent, selective, and resistance-breaking inhibitors of AChE1 as a promising approach for future insecticide development.