201732-43-6

Basic information

• Product Name: (R)-4-amino-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}-5-methyl-2,6-[1H,3H]-pyrimidione
• Synonyms: (R)-4-amino-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}-5-methyl-2,6-[1H,3H]-pyrimidione
• CAS NO: 201732-43-6
• Molecular Weight: 573.764
• Mol File: 201732-43-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-4-amino-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}-5-methyl-2,6-[1H,3H]-pyrimidione(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-amino-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}-5-methyl-2,6-[1H,3H]-pyrimidione(201732-43-6)
• EPA Substance Registry System: (R)-4-amino-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}-5-methyl-2,6-[1H,3H]-pyrimidione(201732-43-6)

Safety Data

• Hazardous Substances Data: 201732-43-6(Hazardous Substances Data)

Upstream product

• 14347-83-2 (R)-2,2-dimethyl-4-benzoxymethyl-1,3-dioxolane 
• 201732-38-9 ((R)-3-Benzyloxy-2-chloromethoxy-propoxy)-tert-butyl-diphenyl-silane 
• 119879-74-2 (R)-1-Benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-propan-2-ol 
• 100-39-0 benzyl bromide 
• 17325-85-8 (2S)-3-(benzyloxy)propane-1,2-diol 
• 15828-63-4 6-aminothymine 

Relevant articles and documents

A cytosine analogue containing a conformationally flexible acyclic linker for triplex formation at sites with contiguous G-C base pairs

Two nucleoside derivatives of the pyrimidine bases T and m(5ox)C have been prepared with flexible acyclic carbohydrate linkers. A new procedure, beginning with (R)-(-)-2,2-dimethyl-1,3-dioxolane-4-methanol permits the preparation of the stereochemically pure acyclic derivatives of both protected nucleoside analogues without contamination by a problematic rearrangement product. By simply increasing the flexibility of the carbohydrate portion of the am(5ox)C nucleoside derivative. 15-mer triplexes containing five contiguous G-C base pairs exhibit a 7-8 °C increase in T(m) value.