201935-41-3

Basic information

• Product Name: 2-chloro-5-Methoxybenzene-1-sulfonyl chloride
• Synonyms: 2-chloro-5-Methoxybenzene-1-sulfonyl chloride;2-Cyano-5-Methoxybenzene-1-sulfonyl chloride;2-Chloro-5-methoxybenzenesulfonyl chloride
• CAS NO: 201935-41-3
• Molecular Formula: C7H6Cl2O3S
• Molecular Weight: 241.09174
• Mol File: 201935-41-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 340.0±32.0 °C(Predicted)
• Appearance: /
• Density: 1.487±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-chloro-5-Methoxybenzene-1-sulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-Methoxybenzene-1-sulfonyl chloride(201935-41-3)
• EPA Substance Registry System: 2-chloro-5-Methoxybenzene-1-sulfonyl chloride(201935-41-3)

Safety Data

• RIDADR: UN3261
• Hazardous Substances Data: 201935-41-3(Hazardous Substances Data)

Usage

General Description

2-chloro-5-Methoxybenzene-1-sulfonyl chloride, also known as mesyl chloride, is a chemical compound with the formula C7H7ClO3S. It is a sulfonyl chloride used in organic synthesis as a reagent for the introduction of the mesyl (methanesulfonyl) group into organic molecules. It is a clear, colorless to pale yellow liquid with a pungent odor. Mesyl chloride is highly reactive and is used as a chlorinating and sulfonylating agent in the production of pharmaceuticals, agrochemicals, and other organic compounds. It is also used in the preparation of sulfonamides, sulfones, and sulfonyl ureas. Additionally, it is a key intermediate for the synthesis of various dyes, pigments, and other fine chemicals. Despite its usefulness, mesyl chloride is toxic and corrosive, requiring careful handling and storage.

Upstream product

• 85006-21-9 2-chloro-5-methoxyaniline hydrochloride 
• 10298-80-3 2-chloro-5-methoxynitrobenzene 
• 2401-24-3 2-chloro-5-methoxyaniline 

Downstream Products

• 1426214-90-5 N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl) phenyl]-2-chloro-5-methoxy-benzenesulfonamide 

Relevant articles and documents

Controllable Effect of Structural Modification of Sulfonylurea Herbicides on Soil Degradation

The study of soil degradation behaviors of sulfonylurea herbicides in relation to their different structural attributes is utmost important for us to comprehend the development of new eco-friendly herbicides. It is postulated that the structural modification of the chemical structures could influence their degradation rates in soil. Nine devised structures were synthesized to study their herbicidal activity as well as their soil degradation behaviors respectively. The novel compounds I-3–I-7 were characterized by UV,1H NMR and13C NMR, MS and EA. Bioassays indicated that most of target compounds displayed superior herbicidal activities in comparison with Chlorsulfuron. Soil degradation results further confirmed our previous assumption that the introduction of electron-donating substituents at 5thposition of the benzene ring distinctly increased their degradation rates, among which dimethylamino and diethylamino groups can adjust the degradation rate to a more favorable status.

ORGANIC COMPOUNDS

There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.