202114-47-4 Usage
Description
D-[UL-13C5]RIBOSE is a stable isotope-labeled compound of D-Ribose, a five-carbon monosaccharide. It is produced through the fermentation of glucose by microorganisms in a culture medium that does not involve the addition of calcium carbonate. The incorporation of the stable isotope 13C in the D-Ribose molecule allows for its use in various applications, particularly in research and development.
Uses
Used in Research and Development:
D-[UL-13C5]RIBOSE is used as a research tool for studying metabolic pathways and enzyme mechanisms. The stable isotope labeling enables researchers to track the compound's movement and interactions within biological systems, providing valuable insights into cellular processes and potential therapeutic targets.
Used in Pharmaceutical Industry:
D-[UL-13C5]RIBOSE is used as a tracer compound in the development of new drugs and therapies. Its stable isotope labeling allows for the monitoring of drug metabolism and pharmacokinetics, which can be crucial in optimizing drug efficacy and safety.
Used in Diagnostic Applications:
In the medical field, D-[UL-13C5]RIBOSE can be employed as a diagnostic agent to help identify and monitor various metabolic disorders and diseases. The stable isotope labeling allows for the detection and quantification of the compound in biological samples, aiding in the diagnosis and treatment of these conditions.
Used in Nutritional Studies:
D-[UL-13C5]RIBOSE can be utilized in nutritional research to investigate the role of D-Ribose in energy metabolism and its effects on athletic performance and recovery. The stable isotope labeling can help researchers better understand the compound's absorption, utilization, and excretion in the human body.
Check Digit Verification of cas no
The CAS Registry Mumber 202114-47-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,2,1,1 and 4 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 202114-47:
(8*2)+(7*0)+(6*2)+(5*1)+(4*1)+(3*4)+(2*4)+(1*7)=64
64 % 10 = 4
So 202114-47-4 is a valid CAS Registry Number.
202114-47-4Relevant articles and documents
Analysis of metabolic pathways via quantitative prediction of isotope labeling patterns: A retrobiosynthetic 13C NMR study on the monoterpene loganin
Eichinger, Dietmar,Bacher, Adelbert,Zenk, Meinhart H.,Eisenreich, Wolfgang
, p. 223 - 236 (2007/10/03)
The monoterpene loganin serves as a precursor in the biosynthetic pathways of numerous indole alkaloids. In contrast to earlier studies, we present evidence that the biosynthesis of loganin in Rauwolfia serpentina cells proceeds mainly via the deoxyxylulose pathway and not by the mevalonate pathway. This conclusion is based on experiments using a R. serpentina cell culture supplied with 13C-labeled samples of glucose, ribose/ribulose, pyruvate or glycerol. Loganin was isolated from biomass, and the hydrolysis of cellular protein afforded amino acids. The isolated metabolites were analyzed by NMR spectroscopy. The 13C-labeling patterns of isolated amino acids were then used to reconstruct the labeling patterns of phosphoenol pyruvate, pyruvate and acetyl CoA. These labeling patterns were subsequently used to predict labeling patterns for dimethylallyl pyrophosphate and isopentenyl pyrophosphate via the mevalonate and deoxyxylulose pathway, respectively. The observed labeling patterns of the terpenoid moieties in loganin were in excellent agreement with the deoxyxylulose prediction. The minor incorporation of mevalonate into loganin observed in earlier studies can be attributed to metabolite exchange between the two terpenoid pathways. The possibility of crosstalk between the two pathways in plants and plant cell cultures stresses the need for a quantitative analysis of general carbon metabolism in order to determine the partitioning between the mevalonate and deoxyxylulose pathway. The present study shows that a wide variety of general metabolic precursors can fulfill this task in conjunction with the retrobiosynthetic concept.
