202131-29-1

Basic information

• Product Name: V⁽¹⁹⁴⁾U₀₂₉₃
• CAS NO: 202131-29-1
• Molecular Weight: 323.143
• Mol File: 202131-29-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: V⁽¹⁹⁴⁾U₀₂₉₃(CAS DataBase Reference)
• NIST Chemistry Reference: V⁽¹⁹⁴⁾U₀₂₉₃(202131-29-1)
• EPA Substance Registry System: V⁽¹⁹⁴⁾U₀₂₉₃(202131-29-1)

Safety Data

• Hazardous Substances Data: 202131-29-1(Hazardous Substances Data)

Upstream product

• 95-56-7 2-hydroxybromobenzene 
• 2491-39-6 2-bromo-2',4'-dihydroxyoacetophenone 

Relevant articles and documents

Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu 4) antagonist: Unexpected 'molecular switch' from a closely related mGlu4 positive allosteric modulator

Herein we report the discovery and SAR of a novel antagonist of metabotropic glutamate receptor 4 (mGlu4). The antagonist was discovered via a molecular switch from a closely related mGlu4 positive allosteric modulator (PAM). This antagonist (VU0448383) displays an IC50 value of 8.2 ± 0.4 μM and inhibits an EC80 glutamate response by 63.1 ± 6.6%.