20224-10-6

Basic information

• Product Name: 2-Cinnamoylbenzimidazole
• Synonyms: 2-Cinnamoylbenzimidazole
• CAS NO: 20224-10-6
• Molecular Formula: C₁₆H₁₂N₂O
• Molecular Weight: 248.27928
• Mol File: 20224-10-6.mol
• Article Data: 18

Chemical Properties

• Melting Point: 201-205 °C
• Boiling Point: 487.4°C at 760 mmHg
• Flash Point: 245.8°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 1.19E-09mmHg at 25°C
• Refractive Index: 1.723
• PKA: 10.30±0.10(Predicted)
• CAS DataBase Reference: 2-Cinnamoylbenzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cinnamoylbenzimidazole(20224-10-6)
• EPA Substance Registry System: 2-Cinnamoylbenzimidazole(20224-10-6)

Safety Data

• Hazardous Substances Data: 20224-10-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H12N2O/c19-15(11-10-12-6-2-1-3-7-12)16-17-13-8-4-5-9-14(13)18-16/h1-11H,(H,17,18)/b11-10+

Upstream product

• 100-52-7 benzaldehyde 
• 939-70-8 2-acetylbenzimidazole 
• 16414-04-3 1-benzimidazol-2-ylethanol 
• 95-54-5 1,2-diamino-benzene 
• 4857-01-6 2-(1H-benzo[d]imidazol-2-yl)ethanol 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 146887-09-4 2,6-bis(1H-benzimidazol-2-yl)-4-phenylpyridine 
• 132308-69-1 4-(benzimidazol-2-yl)-6-phenylpyrimidin-2-amine 
• 132308-52-2 2-(5-phenyl-4,5-dihydro-1H-3-pyrazolyl)-1H-benzimidazole 
• 1164474-59-2 (E)-1-[1-(2-Oxo-2-p-tolyl-ethyl)-1H-benzoimidazol-2-yl]-3-phenyl-propenone 
• 1250436-83-9 C₁₇H₁₄N₄O 
• 1250436-95-3 C₁₇H₁₅N₅S 
• 58035-20-4 2-(1,5-diphenyl-4,5-dihydro-1H-3-pyrazolyl)-1H-benzimidazole 
• 63330-81-4 2-(5-phenyl-4,5-dihydroisoxazol-3-yl)benzimidazole 
• 1454686-79-3 N-(4-(2-(3-(1H-benzo[d]imidazol-2-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethoxy)phenyl)acetamide 
• 1456802-26-8 6-(1H-benzo[d]imidazol-2-yl)-2-(benzylideneamino)-4-phenylnicotinonitrile 
• 1456802-00-8 6-(1H-benzo[d]imidazol-2-yl)-2-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-phenylnicotinonitrile 
• 1285695-39-7 2-amino-6-(1H-benzo[d]imidazol-2-yl)-4-phenylnicotinonitrile 
• 1575823-96-9 6-(1H-benzo[d]imidazol-2-yl)-2-(2-(3-nitrophenyl)-4-oxothiazolidin-3-yl)-4-phenylnicotinonitrile 

Relevant articles and documents

Design and structure-activity relationships anticandidosic of diazaheteroaryl functionalized by Micha?l acceptors

Benzimidazole and imidazopyridine heterocycles associated with Micha?l acceptors have shown strong anticandidosic potential in our previous work. After a decade of research, we have designed, synthesized and evaluated the anticandidosic activities of seve

Applications of benzimidazole derivatives in prevention and treatment of agricultural plant diseases

The invention relates to the field of medicinal chemistry, and discloses applications of any compound from benzimidazole derivatives Y-0 to Y-12 in prevention and treatment of agricultural plant diseases. It is found through bioactivity test that compounds have certain inhibition activity on six plant fungi including Phyllosticta zeae, botrytis cinerea, sclerotinia sclerotiorum, magnaporthe grisea, rhizoctonia solani and fusarium oxysporum, the inhibition rate of part of the compounds on the six pathogenic fungi under 100 ppm reaches 70% or above, and particularly, the growth of Phyllosticta zeae is almost completely inhibited. The compounds are simple to prepare and cheap and easily available in raw materials, and are expected to be developed into novel bactericides.

Synthesis and characterization of novel benzimidazole embedded 1,3,5-trisubstituted pyrazolines as antimicrobial agents

Efficient syntheses of some new substituted pyrazoline derivatives linked to substituted benzimidazole scaffold were performed by multistep reaction sequences. All the synthesized compounds were characterized using elemental analysis and spectral studies (IR, 1D/2D NMR techniques and mass spectrometry). The synthesized compounds were screened for their antimicrobial activity against selected Gram-positive and Gram-negative bacteria, and fungi strain. The compounds with halo substituted phenyl group at C5 of the 1-phenyl pyrazoline ring (15, 16 and 17) showed significant antibacterial activity. Among the screened compounds, 17 showed most potent inhibitory activity (MIC = 64 μg mL-1) against a bacterial strain. The tested compounds were found to be almost inactive against the fungal strain C. albicans, apart from pyrazoline-1-carbothiomide 21, which was moderately active.