20226-99-7

Basic information

• Product Name: (1R,2S)-1-HYDROXY-1,2,3-PROPANETRICARBOXYLIC ACID MONOPOTASSIUM SALT
• Synonyms: DS-(+)-THREO-ISOCITRIC ACID MONOPOTASSIUM SALT;(1R,2S)-1-HYDROXY-1,2,3-PROPANETRICARBOXYLIC ACID MONOPOTASSIUM SALT;(+)-Potassium Ds-threo-isocitrate monobasic;threo ds(+)isocitric acid monopotassium;Ds-(+)-threo-Isocitric acid monopotassium salt, (1R,2S)-1-Hydroxy-1,2,3-propanetricarboxylic acid monopotassium salt;(+)-PotassiuM Ds-threo-isocitrate Monobasic >=98.0% (NT)
• CAS NO: 20226-99-7
• Molecular Formula: C₆H₇O₇*K
• Molecular Weight: 230.21
• Mol File: 20226-99-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: ~185 °C (dec.)
• Boiling Point: 329.6°C at 760 mmHg
• Flash Point: 167.4°C
• Appearance: /
• Vapor Pressure: 1.3E-05mmHg at 25°C
• BRN: 3767339
• CAS DataBase Reference: (1R,2S)-1-HYDROXY-1,2,3-PROPANETRICARBOXYLIC ACID MONOPOTASSIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S)-1-HYDROXY-1,2,3-PROPANETRICARBOXYLIC ACID MONOPOTASSIUM SALT(20226-99-7)
• EPA Substance Registry System: (1R,2S)-1-HYDROXY-1,2,3-PROPANETRICARBOXYLIC ACID MONOPOTASSIUM SALT(20226-99-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 20226-99-7(Hazardous Substances Data)

Usage

Description

(1R,2S)-1-HYDROXY-1,2,3-PROPANETRICARBOXYLIC ACID MONOPOTASSIUM SALT, also known as (+)-Potassium Ds-threo-isocitrate monobasic, is a chemical compound with a specific stereochemistry. It is a monopotassium salt derived from the hydroxy acid isocitric acid, featuring a unique arrangement of hydrogen atoms at the first and second carbon positions in the molecule.

Uses

Used in Enzyme Activity Assessment:
(1R,2S)-1-HYDROXY-1,2,3-PROPANETRICARBOXYLIC ACID MONOPOTASSIUM SALT is used as a substrate for the assessment of isocitrate dehydrogenase 2 (IDH2) activity by the Kornberg method. This application is crucial in the study of enzyme kinetics and the evaluation of IDH2 function in various biological processes.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (1R,2S)-1-HYDROXY-1,2,3-PROPANETRICARBOXYLIC ACID MONOPOTASSIUM SALT may be used as a starting material or intermediate in the synthesis of various drugs targeting metabolic pathways and enzyme inhibition.
Used in Biochemical Education:
As an educational tool, (1R,2S)-1-HYDROXY-1,2,3-PROPANETRICARBOXYLIC ACID MONOPOTASSIUM SALT can be employed in teaching laboratories to demonstrate the principles of stereochemistry and enzyme kinetics, providing students with hands-on experience in biochemical analysis.
Used in Analytical Chemistry:
In the field of analytical chemistry, (1R,2S)-1-HYDROXY-1,2,3-PROPANETRICARBOXYLIC ACID MONOPOTASSIUM SALT may be utilized as a reference compound for the development and validation of analytical methods, such as high-performance liquid chromatography (HPLC) or mass spectrometry, for the separation and quantification of stereoisomers.

InChI:InChI=1/C6H8O7.K/c7-3(8)1-2(5(10)11)4(9)6(12)13;/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13);/q;+1/p-1/t2-,4+;/m0./s1