202288-09-3

Basic information

• Product Name: 4-tert-butyl-N-[6-(4-hydroxy-butoxy)-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-benzenesulfonamide
• CAS NO: 202288-09-3
• Molecular Weight: 501.604
• Mol File: 202288-09-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-tert-butyl-N-[6-(4-hydroxy-butoxy)-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-tert-butyl-N-[6-(4-hydroxy-butoxy)-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-benzenesulfonamide(202288-09-3)
• EPA Substance Registry System: 4-tert-butyl-N-[6-(4-hydroxy-butoxy)-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-benzenesulfonamide(202288-09-3)

Safety Data

• Hazardous Substances Data: 202288-09-3(Hazardous Substances Data)

Upstream product

• 110-63-4 Butane-1,4-diol 
• 150727-24-5 4-tert-butyl-N-[6-chloro-5-(o-methoxyphenoxy)-4-pyrimidinyl]-benzene sulfonamide 
• 150727-23-4 4,6-dichloro-5-(o-methoxyphenoxy)-pyrimidine 
• 202288-08-2 5-(2-methoxy-phenoxy)-1H-pyrimidine-4,6-dione 
• 150726-89-9 (2-methoxyphenoxy)-malonic acid dimethyl ester 
• 90-05-1 2-methoxy-phenol 

Relevant articles and documents

Synthesis and structure-activity relationships of potent and orally active sulfonamide ETB selective antagonists

The synthesis and structure-activity relationships of a series of N-pyrimidinyl benzenesulfonamides as ETB selective antagonists are described. N-Isoxazolyl benzenesulfonamide 1a, previously reported, was selected as a lead compound, and isosteric replacement of the isoxazole ring of 1a with a pyrimidine ring led to the discovery of the highly potent ETB selective antagonist 6e with oral bioavailability. Modification of the terminal aldehyde group at the 6-position of the pyrimidine ring was investigated, and malonate 15b and acylhydrazone 16f were found to be equipped to aldehyde 6e. Compound 6e showed ETB antagonistic activity on in vivo evaluation. Copyright