202586-57-0Relevant articles and documents
Synthesis method of imazethapyr
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Paragraph 0022; 0028; 0030, (2021/01/11)
The invention relates to a synthesis method of imazethapyr, wherein the synthesis method comprises the steps: by using 5-ethylpyridine-2,3-dicarboxylic acid as a raw material, reacting with acetic anhydride to generate 5-methylpyridine-2,3-dicarboxylic anhydride; and under a low-temperature condition, continuing to react with alcohol to generate a compound represented by a structural formula (I),carrying out ring closing reaction with 2-amino-2,3-dimethylbutyramide under an alkaline condition, extracting to regulate the pH value, and thus obtaining the imazapyr product. The method has the advantages that the method is high in route reaction speed, extremely high in product purity, high in yield, mild in reaction condition, free of isomers and few in three wastes, the synthesis process isextensive, the reaction condition is optimized, the equipment cost of the reaction is reduced, the produced product is easy to separate, and the production process is simplified. The structural formula (I) is described in the specification.