2026-70-2Relevant articles and documents
Effect of the ancillary ligand in N-heterocyclic carbene iridium(III) catalyzed N-alkylation of amines with alcohols
Feng, Xinshu,Huang, Ming
, (2021/06/21)
A series of air-stable N-heterocyclic carbene (NHC) Ir(III) complexes (Ir1-6), bearing various combinations of chlorine, pyridine and NHC ligands, were assayed for the N-alkylation of amines with alcohols. It was found that Ir3, with two monodentate 1,3-bis-methyl-imidazolylidene (IMe) ligands, emerged as the most active complex. A large variety of amines and primary alcohols were efficiently converted into mono-N-alkylated amines in 53–96% yields. As a special highlight, for the challenging MeOH, selective N-monomethylation could be achieved using KOH as a base under an air atmosphere. Moreover, this catalytic system was successfully applied to the gram-scale synthesis of some valuable compounds.
Novel phosphoramidite ligand, preparation method thereof and application thereof in asymmetric carbonylation reaction
-
Paragraph 0052-0054; 0056, (2021/09/29)
I Application of the asymmetric II carbonylating reaction strategy, and the synthetic problems of the hexahydropyrrolindole alkaloid and the dimeric cyclic amine alkaloid are effectively solved by using the monodentate chiral ligand to solve the problem of low enantioselectivity in the asymmetric domino Heck Heck and carbonylation reaction.
Highly Efficient Binuclear Copper-catalyzed Oxidation of N,N-Dimethylanilines with O2
Liu, Yuxia,Yan, Yonggang,Xue, Dong,Wang, Zhongfu,Xiao, Jianliang,Wang, Chao
, p. 2221 - 2225 (2020/03/23)
A binuclear copper-salicylate complex, [Cu(Sal)2(NCMe)]2 (Sal=salicylate), was found to be an active catalyst for the oxidation of N,N-dimethylanilines by O2, affording the corresponding N-methyl-N-phenylformamides as major products. The reactions were carried out with a O2 balloon and the S/C (substrate/catalyst ratio) of the model reaction could be up to 1×105, providing a practical and highly efficient catalytic protocol for accessing N-methyl-N-phenylformamides.
