202925-09-5

Basic information

• Product Name: 4-CHLORO-3-FLUOROBENZALDOXIME
• Synonyms: 4-CHLORO-3-FLUOROBENZALDOXIME;4-CHLORO-3-FLUOROBENZALDOXIME, 97% MIN.
• CAS NO: 202925-09-5
• Molecular Formula: C₇H₅ClFNO
• Molecular Weight: 173.57
• Mol File: 202925-09-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 240.448 °C at 760 mmHg
• Flash Point: 99.22 °C
• Appearance: /
• Density: 1.327 g/cm³
• Vapor Pressure: 0.021mmHg at 25°C
• Refractive Index: 1.533
• CAS DataBase Reference: 4-CHLORO-3-FLUOROBENZALDOXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-3-FLUOROBENZALDOXIME(202925-09-5)
• EPA Substance Registry System: 4-CHLORO-3-FLUOROBENZALDOXIME(202925-09-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 202925-09-5(Hazardous Substances Data)

Usage

General Description

4-Chloro-3-Fluorobenzaldoxime is a benzaldoxime compound characterized by the presence of chlorine and fluorine constituents. Its systematic name is 4-chloro-3-fluorobenzonitrile oxime. This organic compound falls under the category of aromatic halides or oximes, which are used broadly in the field of organic chemistry, manufacturing of pharmaceuticals, agrochemical compounds, and polymer resins. The chemical, like all aldoximes, is typically distinguished by the presence of the functional group =N-OH attached to an sp2 hybridized carbon atom. Its physical and chemical characteristics, such as boiling point, density, solubility and stability, will vary depending on its specific formulation.

InChI:InChI=1/C7H5ClFNO/c8-6-2-1-5(4-10-11)3-7(6)9/h1-4,11H/b10-4+

Upstream product

• 5527-95-7 4-chloro-3-fluorobenzaldehyde 

Downstream Products

• 430534-91-1 4-chloro-3-fluorobenzoylchloride oxime 
• 1325228-72-5 C₁₂H₈Cl₂FNO₃ 
• 1325228-74-7 C₁₀H₆Cl₂FNO₂ 
• 1239576-24-9 4-chloro-3-(4-chloro-3-fluorophenyl)isoxazole-5-carboxylic acid 
• 1239576-12-5 4-chloro-3-(4-chloro-3-fluorophenyl)-N-((1R,3S)-3-hydroxycyclohexyl)isoxazole-5-carboxamide 
• 1126636-64-3 C₁₀H₇ClFNO₂ 

Relevant articles and documents

Triazole alcohol derivative as well as preparation method and application thereof

The invention relates to a triazole alcohol derivative as well as a preparation method and application thereof. The chemical structure of the triazole alcohol derivative is shown as a formula I, R1 represents a benzene ring or a substituted benzene ring, and substituent groups of the substituted benzene ring can be located at all positions of the benzene ring, can be mono-substituted or multi-substituted, and can be selected from a) halogen which is F and Cl; b) an electron withdrawing group which is cyano or trifluoromethyl; c ) a lower alkyl of 1-4 carbon atoms or a halogen substituted loweralkyl; and d) lower alkoxy of 1-4 carbon atoms or halogen substituted lower alkoxy. The compound of the invention has strong antifungal activity, has the advantages of low toxicity, wide antibacterial spectrum and the like, and can be used for preparing antifungal drugs.

Discovery of Natural Product-Based Fungicides (II): Semisynthesis and Biological Activity of Sarisan Attached 3-Phenylisoxazolines as Antifungal Agents

Many phytopathogenic fungi cause severe damage to crop yields. In continuation of our research aimed at the discovery and development of natural products-based fungicides, a series of thirty-one sarisan attached 3-phenylisoxazolines were synthesized and evaluated for their antifungal activities against five phytopathogenic fungi (B. cinerea, C. lagenarium, A. solani, F. solani, and F. graminearum). Among all title sarisan derivatives, compounds IV2, IV14 and IV23 showed potent antifungal activity against some phytopathogenic fungi. In particular, compound IV2 exhibited a broad-spectrum and more potent antifungal activity against A. solani, F. solani, and F. graminearum than the commercial fungicide Hymexazol. In addition, compounds IV2, IV14 and IV23 also displayed relative low toxicity on normal NRK-52E cells. This work will give some insights into the development of sarisan derivatives as new fungicide candidates in plant protection.

Synthesis and in vitro biological evaluation of novel coumarin derivatives containing isoxazole moieties on melanin synthesis in B16 cells and inhibition on bacteria

A novel series of coumarin derivatives 6a–o, bearing isoxazole moieties were designed and synthesized. After that, they were evaluated for melanin synthesis in murine B16 cells and inhibitory effect on the growth of CA (Candida albicans), EC (Escherichia coli), SA (Staphylococcus aureus). It was found that eleven compounds (6b–f, 6j–o) showed a better activity on melanin synthesis than positive control (8-MOP). Among them, compounds 6d (242%) and 6f (390%), with nearly 1.6 and 2.6-fold potency compared with 8-MOP (149%) respectively, were recognized as the most promising candidate hits for further pharmacological study of anti-vitiligo. Seven halogen substituted compounds exhibited moderate antimicrobial activity against CA. It is interesting that 6e–f and 6l–m, which had two halogens on the benzene showed a comparable activity with Amphotericin B against CA. The evaluation of melanin synthesis in B16 cells and inhibitory effect on bacteria of above structurally diverse derivatives had also led to an outline of structure-activity relationship.