20295-34-5 Usage
Description
Cyclopropanecarbothioamide is a chemical compound utilized in various chemical reactions and purification processes. It is particularly known for its role in the single-step preparation of thiazolo[5,4-b]pyridine and thiazolo[5,4-c]pyridine derivatives from chloronitropyridines and thioamides or thioureas. Additionally, it has been found useful in proteomics studies and has been employed in the synthesis of novel heterocyclic compounds, such as CE-125, which demonstrates potential in enhancing working memory and modulating the dopamine receptor D1R in the frontal cortex of Sprague-Dawley rats.
Uses
Used in Chemical Synthesis:
Cyclopropanecarbothioamide is used as a purification agent for the single-step preparation of thiazolo[5,4-b]pyridine and thiazolo[5,4-c]pyridine derivatives from chloronitropyridines and thioamides or thioureas. This application is crucial for obtaining pure and well-defined products in chemical synthesis.
Used in Proteomics Studies:
In the field of proteomics, Cyclopropanecarbothioamide serves as a valuable chemical, aiding in the study of proteins and their interactions within biological systems.
Used in Pharmaceutical Research:
Cyclopropanecarbothioamide has been utilized in the synthesis of CE-125, a novel heterocyclic compound that has shown promise in improving working memory and modulating the dopamine receptor D1R in the frontal cortex of Sprague-Dawley rats. This application highlights its potential in the development of new pharmaceuticals targeting cognitive functions and neurological disorders.
References
https://www.alfa.com/en/catalog/H32315/
Hussein, A. M., et al. "A novel heterocyclic compound improves working memory in the radial arm maze and modulates the dopamine receptor D1R in frontal cortex of the Sprague-Dawley rat." Behavioural Brain Research 332(2017):308-315.
Check Digit Verification of cas no
The CAS Registry Mumber 20295-34-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,2,9 and 5 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 20295-34:
(7*2)+(6*0)+(5*2)+(4*9)+(3*5)+(2*3)+(1*4)=85
85 % 10 = 5
So 20295-34-5 is a valid CAS Registry Number.
InChI:InChI=1/C4H7NS/c5-4(6)3-1-2-3/h3H,1-2H2,(H2,5,6)
20295-34-5Relevant articles and documents
Preparation of primary thioamides from nitriles using sodium hydrogen sulfide and diethylamine hydrochloride
Boys, Mark L.,Downs, Victoria L.
, p. 295 - 298 (2006)
Primary thioamides are prepared in moderate to excellent yields by treating nitriles with sodium hydrogen sulfide and diethylamine hydrochloride in an appropriate solvent with mild heating. Copyright Taylor & Francis LLC.
Domino aryne precursor: Efficient construction of 2,4-disubstituted benzothiazoles
Shi, Jiarong,Qiu, Dachuan,Wang, Juan,Xu, Hai,Li, Yang
supporting information, p. 5670 - 5673 (2015/05/20)
An aryne precursor with a potential to perform domino aryne chemistry was proposed and synthesized. The reaction of this reagent with benzothioamide derivatives could afford 2,4-disubstituted benzothiazole with sequential incorporation of C-S, C-N, and C-C bonds on the consecutive three positions of the aryne precursor.
2-CYCLOPROPYL-THIAZOLE DERIVATIVES
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Page/Page column 12; 22, (2010/09/07)
The invention relates to selected 2-cyclopropyl-thiazole derivatives of the formula (I) wherein B, Y and R1 are as described in the description; to salts and especially pharmaceutically acceptable salts thereof, and to the use of such compounds use as med
