203059-80-7

Basic information

• Product Name: 1,2-DIFLUORO-4,5-DIMETHOXYBENZENE
• Synonyms: 1,3-DIBROMO-2-CHLORO-5-FLUOROBENZENE 99+%;1,2-Difluoro-4,5-dimethoxybenzene,90%;1,2-DIFLUORO-4,5-DIMETHOXYBENZENE
• CAS NO: 203059-80-7
• Molecular Formula: C₈H₈F₂O₂
• Molecular Weight: 174.14
• Product Categories: Anisole;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds;Ethers;Organic Building Blocks;Oxygen Compounds
• Mol File: 203059-80-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 41-43 °C(lit.)
• Boiling Point: 183.7 °C at 760 mmHg
• Flash Point: 198 °F
• Appearance: white to yellow crystal powder
• Density: 1.226 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.04mmHg at 25°C
• Refractive Index: 1.455
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Toluene
• CAS DataBase Reference: 1,2-DIFLUORO-4,5-DIMETHOXYBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DIFLUORO-4,5-DIMETHOXYBENZENE(203059-80-7)
• EPA Substance Registry System: 1,2-DIFLUORO-4,5-DIMETHOXYBENZENE(203059-80-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 203059-80-7(Hazardous Substances Data)

Usage

Chemical Properties

whitetoyelloecrystalpowde

InChI:InChI=1/C8H8F2O2/c1-11-7-3-5(9)6(10)4-8(7)12-2/h3-4H,1-2H3

Upstream product

• 186581-53-3 diazomethane 
• 147300-08-1 4,5-difluorocatechol 

Downstream Products

• 246029-17-4 4,5-difluoro-2-methoxyphenol 
• 1193391-73-9 (6,7-difluoro-2,3-dihydro-1,4-benzodioxin-2-yl)methyl 4-methylbenzenesulfonate 
• 1193392-75-4 4,5-difluoro-2-(oxiran-2-ylmethoxy)phenol 
• 1193392-74-3 2-[(4,5-difluoro-2-methoxyphenoxy)methyl]oxirane 
• 1188413-06-0 C₁₂H₁₆F₂O₅S 
• 1188412-64-7 (S)-2-(2,3-difluoro-5,6-dimethoxy-phenyl)-1-methyl-ethylamine 
• 1188412-61-4 (2R)-1-(2,3-difluoro-5,6-dimethoxyphenyl)propan-2-ol 

Relevant articles and documents

Transformation of difluorinated phenols by Penicillium frequentans Bi 7/2

The Penicillium frequentans strain Bi 7/2, using phenol as a sole source of carbon and energy, transformed the fluorinated phenols 2,3-, 2,4-, 2,5- and 3,4-difluorophenol rapidly. After growth on phenol, resting mycelia of the fungus converted the difluorophenols completely at an initial concentration of 0.5mM within 6 hours. The corresponding difluorinated catechols were found to be intermediates of all difluorophenols investigated. A relatively unspecific phenol hydroxylase catalyzed this hydroxylation step and showed activities towards all difluorophenols tested. One difluorocatechol was formed from each difluorophenol substituted with fluorine in the ortho-position, whereas two catechols were formed from 3,4-difluorophenol, due to its two vacant ortho-positions. A partial defluorination (50-77%) was observed in all cases.