20306-31-4

Basic information

• Product Name: Benzenemethanol, 4-chloro-, formate
• CAS NO: 20306-31-4
• Molecular Formula: C8H7ClO2
• Molecular Weight: 170.595
• Mol File: 20306-31-4.mol
• Article Data: 31

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 4-chloro-, formate(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 4-chloro-, formate(20306-31-4)
• EPA Substance Registry System: Benzenemethanol, 4-chloro-, formate(20306-31-4)

Safety Data

• Hazardous Substances Data: 20306-31-4(Hazardous Substances Data)

Usage

Chemical compound

Benzenemethanol, 4-chloro-, formate

Derived from

4-chloro benzyl alcohol and formic acid

Common uses

intermediate in pharmaceuticals, agrochemicals, and dyes production, manufacturing perfumes and flavorings

Odor

mild, sweet

Stability

relatively stable under normal conditions

Health hazards

potential health hazards, handle with care and follow safety guidelines

Upstream product

• 873-76-7 para-Chlorobenzyl alcohol 
• 109-94-4 formic acid ethyl ester 
• 64-18-6 formic acid 
• 96-26-4 dihydroxyacetone 
• 68-12-2 N,N-dimethyl-formamide 
• 107-31-3 Methyl formate 
• 18484-03-2 2-(4-chlorobenzyloxy)tetrahydro-2H-pyran 
• 14856-74-7 4-chlorobenzyltrimethylsilyl ether 

Downstream Products

• 1396689-49-8 4-chlorobenzyl 3-(4-methoxyphenyl)propanoate 
• 1396689-62-5 4-chlorobenzyl 2-(4-methoxyphenyl)propanoate 
• 1042670-82-5 3a,4-dihydro-6-(4-methylphenyl)-1H-cyclopenta[c]furan-5(3H)-one 
• 635751-96-1 2-(3,5-dimethylphenyl)-7-oxabicyclo[3.3.0]oct-1-en-3-one 
• 862972-91-6 6-(4-chlorophenyl)-3a,4-dihydro-1H-cyclopenta[c]furan-5(3H)-one 
• 1042670-86-9 3a,4-dihydro-6-(4-fluorophenyl)-1H-cyclopenta[c]furan-5(3H)-one 
• 862972-92-7 2-(2-methylphenyl)-7-oxabicyclo[3.3.0]oct-1-en-3-one 
• 903595-00-6 3a,4-dihydro-6-[4-(trifluoromethyl)phenyl]-1H-cyclopenta[c]furan-5(3H)-one 
• 133788-00-8 6-phenyl-3a,4-dihydro-1H-cyclopenta[c]furan-5(3H)-one 

Relevant articles and documents

Making Carbonyls of Amides Nucleophilic and Hydroxyls of Alcohols Electrophilic Mediated by SO2F2 for Synthesis of Esters from Amides

We discovered that with the promotion of sulfuryl fluoride, the carbonyl groups of amides performed as nucleophiles while the hydroxyl groups of alcohols were activated to functionalize as electrophiles. This study displayed that the amide C-N bonds could be easily cleaved with delicate nucleophiles to form the ester C-O bonds at room temperature without using transition metals. The broad substrate scope and excellent functional group compatibility were proved with 44 examples in up to 99% yields.

Method for preparing formate-type compound

The invention discloses a method for preparing a formate-type compound. The method comprises the following steps of: adopting an alcohol-type compound and 1,3-dihydroxyacetone as reaction raw materials, and under the existence of a composite catalyst and an oxidant, reacting for 2-48 hours in a reaction medium in a reactor at a reaction temperature of 25-100 DEG C so as to obtain the formate-typecompound. The method disclosed by the invention is simple, and is mild in reaction condition, and by the method, a target product can be obtained by low cost and high yield; the used catalyst has highcatalytic activity, and is easily separated from a reaction system to be repeatedly used; the whole process is environment-friendly, and the reaction raw material (1,3-dihydroxyacetone) is easily converted from a side product (glycerol) of biodiesel, so that the utilization of the glycerol is promoted.

N-Heterocyclic Carbene Catalyzed Transformylation

The N-heterocyclic carbene (NHC) catalyzed transformylation has been developed for the conversion of 1°, 2°, and 3° alcohols to the corresponding formates. The reaction employs low catalyst loadings and methyl formate as the formyl transfer reagent. The scope of the reaction is broad with 23 examples reported with good yields (59-96%). The reaction is insensitive to common nitrogen and oxygen protecting groups and can be achieved in the presence of a number of heterocycles.