203065-88-7

Basic information

• Product Name: 2-(4-TRIFLUOROMETHYLPHENYL)PYRIDINE
• Synonyms: 2-(4-TRIFLUOROMETHYLPHENYL)PYRIDINE
• CAS NO: 203065-88-7
• Molecular Formula: C₁₂H₈F₃N
• Molecular Weight: 223.19
• Mol File: 203065-88-7.mol
• Article Data: 86

Chemical Properties

• Melting Point: gt. 74.0 to 78.0 °C
• Boiling Point: 266.362°C at 760 mmHg
• Flash Point: 114.892°C
• Appearance: white to yellow/solid
• Density: 1.23g/cm³
• Vapor Pressure: 0.014mmHg at 25°C
• Refractive Index: 1.506
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: air sensitive
• CAS DataBase Reference: 2-(4-TRIFLUOROMETHYLPHENYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-TRIFLUOROMETHYLPHENYL)PYRIDINE(203065-88-7)
• EPA Substance Registry System: 2-(4-TRIFLUOROMETHYLPHENYL)PYRIDINE(203065-88-7)

Safety Data

• Hazardous Substances Data: 203065-88-7(Hazardous Substances Data)

Usage

General Description

2-(4-Trifluoromethylphenyl)pyridine is a chemical compound with the molecular formula C12H8F3N. It is a pyridine derivative with a trifluoromethylphenyl group attached to the 2-position of the pyridine ring. 2-(4-TRIFLUOROMETHYLPHENYL)PYRIDINE is used as a building block in organic synthesis and as a reagent in pharmaceutical and agrochemical research. It is known for its strong electron-withdrawing properties due to the presence of the trifluoromethyl group, making it valuable in the creation of novel compounds with desirable properties. It may also have potential applications in the development of new materials and in medicinal chemistry due to its unique structure and reactivity.

InChI:InChI=1/C12H8F3N/c13-12(14,15)10-6-4-9(5-7-10)11-3-1-2-8-16-11/h1-8H

Upstream product

• 109-09-1 2-chloropyridine 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 98-56-6 4-chlorobenzotrifluoride 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 109-04-6 2-bromo-pyridine 
• 455-13-0 4-Iodobenzotrifluoride 
• 13737-04-7 2-(trimethylsilyl)pyridine 
• 21970-13-8 (pyridin-2-yl)magnesium bromide 
• 402-51-7 4-(trifluoromethyl)phenylmagnesium bromide 
• 33675-27-3 trimethylpyridin-2-ylammonium iodide 
• 125102-17-2 (4-(trifluoromethyl)phenyl)zinc(II) chloride 
• 110-86-1 pyridine 
• 873066-23-0 4-trifluoromethylphenylboronic dimethyl ester 
• 694-59-7 pyridine N-oxide 

Downstream Products

• 1085411-81-9 (E)-2-(2-styryl-4-(trifluoromethyl)phenyl)pyridine 
• 1101187-19-2 C₁₈H₁₈F₃NO₂ 
• 1151554-19-6 2,2'-{5,5'-bis(trifluoromethyl)-1,1'-biphenyl-2,2'-diyl}bispyridine 
• 1128193-21-4 ethyl 6-(2-pyridyl)-3-trifluoromethylbenzoate 
• 1128193-23-6 C₁₈H₁₆F₃NO₄ 
• 1219699-53-2 C₁₃H₁₀F₃NS 
• 1219699-65-6 C₁₄H₁₂F₃NS₂ 
• 1236046-63-1 (phenyl)(2-(pyridin-2-yl)-5-(trifluoromethyl)phenyl)methanone 
• 1240787-02-3 2-(2,6-di((E)-oct-4-en-4-yl)-4-(trifluoromethyl)phenyl)pyridine 
• 1251668-10-6 2-(4'-methoxy-5-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)pyridine 
• 1261287-67-5 2-(2-(1-phenylethyl)4-(trifluoromethyl)phenyl)pyridine 
• 1261287-68-6 2-(2-phenethyl-4-(trifluoromethyl)phenyl)pyridine 
• 158461-30-4 2-(2-Nitro-4-trifluoromethyl-phenyl)-pyridine 
• 1379667-23-8 4-methyl-N-(2-(pyridin-2-yl)-5-(trifluoromethyl)phenyl)benzenesulfonamide 

Relevant articles and documents

Photoluminescence and electroluminescence of four platinum complexes with trifluoromethyl-substituted 2-phenylpyridine and tetraphenylimidodiphosphinate ligands

Four cyclometalated platinum complexes with trifluoromethyl-substituted 2-phenylpyridine at different positions on its phenyl group as the main ligands and tetraphenylimidodiphosphinate as the ancillary ligand, Pt1-Pt4 (Pt1 is a trifluoromethyl-free compl

Organocatalytic synthesis of (Het)biaryl scaffoldsviaphotoinduced intra/intermolecular C(sp2)-H arylation by 2-pyridone derivatives

A uniqueN,O-bidentate ligand 6-oxo-1,6-dihydro-pyridone-2-carboxylic acid dimethylamide (L1) catalyzed direct C(sp2)-H (intra/intermolecular) arylation of unactivated arenes has been developed to expedite access to (Het)biaryl scaffolds under UV-irradiation at room temperature. The protocol tolerated diverse functional groups and substitution patterns, affording the target products in moderate to excellent yields. Mechanistic investigations were also carried out to better understand the reaction pathway. Furthermore, the synthetic applicability of this unified approach has been showcasedviathe construction of biologically relevant 4-quinolone, tricyclic lactam and sultam derivatives.

Borenium-Catalyzed Reduction of Pyridines through the Combined Action of Hydrogen and Hydrosilane

Mesoionic carbene-stabilized borenium ions efficiently reduce substituted pyridines to piperidines in the presence of a hydrosilane and a hydrogen atmosphere. Control experiments and deuterium labeling studies demonstrate reversible hydrosilylation of the pyridine, enabling full reduction of the N-heterocycle under milder conditions. The silane is a critical reaction component to prevent adduct formation between the piperidine product and the borenium catalyst.

Nickel-Catalyzed Reductive 2-Pyridination of Aryl Iodides with Difluoromethyl 2-Pyridyl Sulfone

A novel nickel-catalyzed reductive cross-coupling between aryl iodides and difluoromethyl 2-pyridyl sulfone (2-PySO2CF2H) enables C(sp2)-C(sp2) bond formation through selective C(sp2)-S bond cleavage, which demonstrates the new reactivity of 2-PySO2CF2H reagent. This method employs readily available nickel catalyst and sulfones as cross-electrophile coupling partners, providing facile access to biaryls under mild reaction conditions without pregeneration of arylmetal reagents.