203314-28-7

Basic information

• Product Name: 2,5-Dibromophenylacetic acid
• Synonyms: 2,5-Dibromophenylacetic acid;2-(2,5-DibroMophenyl)acetic acid;2,5-Dibromobenzeneacetic acid;Dibromophenylacetic acid
• CAS NO: 203314-28-7
• Molecular Formula: C₈H₆Br₂O₂
• Molecular Weight: 293.94004
• Mol File: 203314-28-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 376.4±27.0 °C(Predicted)
• Appearance: /
• Density: 1.969±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.87±0.10(Predicted)
• CAS DataBase Reference: 2,5-Dibromophenylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dibromophenylacetic acid(203314-28-7)
• EPA Substance Registry System: 2,5-Dibromophenylacetic acid(203314-28-7)

Safety Data

• Hazardous Substances Data: 203314-28-7(Hazardous Substances Data)

Usage

Description

2,5-Dibromophenylacetic acid is an organic compound characterized by the presence of two bromine atoms at the 2nd and 5th positions of a phenyl ring, with an acetic acid group attached to the benzene ring. This chemical structure endows it with specific reactivity and properties that make it useful in various applications.

Uses

Used in Pharmaceutical Industry:
2,5-Dibromophenylacetic acid is used as a reactant for the synthesis of MK-8742, a potent inhibitor of the Hepatitis C Virus (HCV) NS5a protein. This application is significant because it aids in the development of treatments for Hepatitis C, a viral disease that affects the liver and can lead to severe health complications if left untreated. The synthesis of MK-8742 utilizing 2,5-Dibromophenylacetic acid highlights its importance in the pharmaceutical industry for creating therapeutic agents against viral infections.

Upstream product

• 74533-21-4 2-(2,5-dibromophenyl)acetonitrile 
• 610-71-9 2,5-dibromobenzoic acid 
• 147034-01-3 (2,5-dibromophenyl)methanol 
• 642091-49-4 2,5-dibromobenzyl chloride 
• 615-59-8 1,4-dibromo-2-methylbenzene 
• 136105-40-3 1,4-dibromo-2-(bromomethyl)benzene 
• 20870-78-4 5-bromo-2-indolin-2-one 
• 106-37-6 1.4-dibromobenzene 
• 91-56-5 indole-2,3-dione 
• 32937-55-6 1-(2,5-dibromophenyl)ethanone 
• 64-19-7 acetic acid 

Downstream Products

• 203314-51-6 (2,5-dibromo-phenyl)-acetyl chloride 
• 1350840-06-0 2-(2,5-dibromophenyl)-N-methoxyacetamide 
• 1296886-68-4 cyclohexyl 2-{1-[(2,5-dibromophenyl)acetyl]piperidin-4-yl}-1,3-thiazole-4-carboxylate 
• 1585969-22-7 5-bromo-2-(2-(2,5-dibromophenyl)-1-iminoethyl)phenol 
• 1585969-24-9 (R)-2-(1-amino-2-(2,5-dibromophenyl)ethyl)-5-bromophenol 
• 1585969-17-0 (R)-5-bromo-2-(5-bromoindolin-2-yl)phenol 
• 1585969-16-9 (6S,12aR)-3,10-dibromo-6-phenyl-12,12a-dihydro-6H-benzo-[5,6][1,3]oxazino[3,4-a]indole 
• 1585969-26-1 (2S,2'S)-di-tert-butyl 2,2'-(5,5'-((S)-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-1-carboxylate) 4-nitrobenzoic acid 
• 1370468-36-2 N,N'-[[(6S)-6-phenyl-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl-[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis[carbamic acid] C,C'-dimethyl ester 
• 1403991-82-1 3-bromophenyl 2-(2,5-dibromophenyl)acetate 
• 1403991-85-4 1-(4-bromo-2-hydroxyphenyl)-2-(2,5-dibromophenyl)ethanone 

Relevant articles and documents

An Improved Process for the Enantioselective Synthesis of HCV NS5A Inhibitor Elbasvir (MK-8742) Chiral Amine Intermediate

Abstract: Large-scale enantioselective synthesis of the chiral amine unit of HCV NS5A inhibitor Elbasvir has been accomplished in six steps, with 55% overall yield. The process includes a highly enantioselective reduction of the NH imine using R-(+)-diphe

Method for synthesizing 2,5-dibromo phenylacetic acid

The invention discloses a method for synthesizing 2,5-dibromo phenylacetic acid. The method comprises the following step: by taking isatin as a raw material, carrying out carbonyl reduction, 5-site bromo reactions and diazotization hydrolysis reactions, thereby obtaining 2,5-dibromo phenylacetic acid, wherein the step of carbonyl reduction is carried out through catalytic hydrogenation reduction;the step of 5-site bromo reactions is carried out with NBS (Bromo-Succinimide) as a bromo agent; and the step of diazotization is carried out with a sodium nitrite/hydrobromic acid system. HBr/cuprousbromide is adopted as a hydrolysis bromo agent. The method has the advantages of being wide in raw material source, mild in reaction condition, high in yield, excellent in quality, low in finished product cost, and the like.

Synthesis of N-alkoxyindol-2-ones by copper-catalyzed intramolecular N-arylation of hydroxamates

The first example of copper-catalyzed intramolecular N-arylation of hydroxamic acid derivatives is presented. Based on this transformation a new method for the synthesis of N-alkoxyindol-2-ones from 2-(2-bromoaryl) acetylhydroxamates has been developed. T