203385-15-3

Basic information

• Product Name: 2-(2-CHLORO-ACETYLAMINO)-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: Ethyl 2-[(chloroacetyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate;Ethyl 2-[(2-chloroacetyl)amino]-5,6-dihydro-4H-cyclopenta[b]thio;ETHYL 2-[(2-CHLOROACETYL)AMINO]-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLATE;AURORA 2489;ART-CHEM-BB B015566;AKOS AU36-M215;AKOS B015566;AKOS BBS-00000907
• CAS NO: 203385-15-3
• Molecular Formula: C₁₂H₁₄ClNO₃S
• Molecular Weight: 287.76
• Mol File: 203385-15-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 502.8 °C at 760 mmHg
• Flash Point: 257.9 °C
• Appearance: /
• Density: 1.391 g/cm³
• Vapor Pressure: 3.07E-10mmHg at 25°C
• Refractive Index: 1.616
• CAS DataBase Reference: 2-(2-CHLORO-ACETYLAMINO)-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-CHLORO-ACETYLAMINO)-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER(203385-15-3)
• EPA Substance Registry System: 2-(2-CHLORO-ACETYLAMINO)-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER(203385-15-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 203385-15-3(Hazardous Substances Data)

Usage

General Description

2-(2-CHLORO-ACETYLAMINO)-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER is a complex chemical compound with a cyclopentathiophene structure, containing a carboxylic acid ethyl ester group. It also includes a chloroacetylamine moiety. 2-(2-CHLORO-ACETYLAMINO)-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER may have potential applications in pharmaceuticals, as a precursor for the synthesis of other organic molecules, or as a research tool in the field of organic chemistry. The presence of the chloroacetylamine group suggests it could have reactivity in certain chemical reactions and may have biological activity. Due to its complexity, this compound would require careful handling and analysis to fully understand its properties and potential uses.

InChI:InChI=1/C12H14ClNO3S/c1-2-17-12(16)10-7-4-3-5-8(7)18-11(10)14-9(15)6-13/h2-6H2,1H3,(H,14,15)

Upstream product

• 4815-29-6 ethyl 2-amino-4H,5H,6H-cyclopentenothiophene-3-carboxylate 
• 79-04-9 chloroacetyl chloride 
• 120-92-3 cyclopentanone 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 307343-77-7 ethyl 2-(2-(3-allyl-3,4-dihydro-4-oxo-5-phenylthieno[2,3-d]pyrimidin-2-ylthio)acetamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate 

Relevant articles and documents

Synthesis and analgesic activities of some 2-(benzazolylacetyl)amino-3- ethoxycarbonylthiophene derivatives

In this study, some 2-[2-(benzazole-2-thioxy)acetylamino]-3- ethoxycarbonylthiophene and 2-[2-(benzazole-1-yl)acetylamino]-3- ethoxycarbonylthiophene compounds were obtained by the reaction of 2-chloroacetylamino-3-ethoxycarbonylthiophene derivatives and a suitable benzazole-2-thione or benzimidazole derivatives. Analgesic activities of the compounds were tested by using tail-flick and tail-immersion methods. It is reported that some of the compounds showed remarkable analgesic activities. Copyright Taylor & Francis Inc.

2-(3,4-dihydro-4-oxothieno[2,3-d]pyrimidin-2-ylthio) acetamides as a new class of falcipain-2 inhibitors. 3. design, synthesis and biological evaluation

The cysteine protease falcipain-2 (FP-2) of Plasmodium falciparum is a principal cysteine protease and an essential hemoglobinase of erythrocytic P. falciparum trophozoites, making it become an attractive target enzyme for developing anti-malarial drugs.

Synthesis and biological evaluation of new cyclopenteno[b]thiophene derivatives as local anesthetic and antiarrhythmic agents

A series of ethyl 2-substituted amino-cyclopenteno[b]thiophen-3-carboxylates was synthesized as a carticaine analogues and evaluated for their local anesthetic and antiarrhythmic activity. Compounds ethyl 2-[1-oxo-2-(ethylamino)ethylamino]- (4a), ethyl 2-