203448-32-2

Basic information

• Product Name: Phenstatin
• CAS NO: 203448-32-2
• Molecular Weight: 318.326
• Mol File: 203448-32-2.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: Phenstatin(CAS DataBase Reference)
• NIST Chemistry Reference: Phenstatin(203448-32-2)
• EPA Substance Registry System: Phenstatin(203448-32-2)

Safety Data

• Hazardous Substances Data: 203448-32-2(Hazardous Substances Data)

Upstream product

• 185698-55-9 2-(3-hydroxy-4-methoxyphenyl)-1-(3',4',5'-trimethoxyphenyl)ethyne 
• 53560-33-1 3,4,5-trimethoxyphenylacetylene 
• 2675-79-8 1-bromo-3,4,5-trimethoxybenzene 
• 1415342-82-3 (3-((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)(3,4,5-trimethoxyphenyl)methanol 
• 621-59-0 isovanillin 
• 30287-15-1 2-methoxyphenyl 2-chloroacetate 
• 118-41-2 Eudesmic acid 
• 90-05-1 2-methoxy-phenol 
• 177329-71-4 5-Bromo-1-(tert-butyldimethylsilyloxy)-2-methoxybenzene 
• 118779-14-9 N-methoxy-N-methyl-3,4,5-trimethoxybenzamide 
• 203448-31-1 N-[(3-tertbutyldimethylsilyl)oxy-4-methoxybenzoyl]morpholine 
• 154083-41-7 3-((tert-butyldimethylsilyl)oxy)-4-methoxybenzoic acid 
• 121042-95-3 (Z)-5-(3-tert-butyldimethylsilyloxy-4-methoxystyryl)-1,2,3-trimethoxybenzene 
• 97315-18-9 p-methoxy-m-(tert-butyldimethylsilyloxy)-benzaldehyde 

Downstream Products

• 229027-06-9 Phosphoric acid mono-[2-methoxy-5-(3,4,5-trimethoxy-benzoyl)-phenyl] ester 
• 22699-97-4 (3,4-dimethoxyphenyl)(3,4,5-trimethoxyphenyl)methanone 
• 944645-51-6 (3,4-dimethoxyphenyl)(3,4,5-trimethoxyphenyl)methanol 
• 138958-69-7 5-[hydroxy(3,4,5-trimethoxyphenyl)methyl]-2-methoxyphenol 
• 203448-30-0 (3-((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone 
• 95041-90-0 erianin 
• 117048-62-1 combrestatin A₄ 
• 185698-55-9 2-(3-hydroxy-4-methoxyphenyl)-1-(3',4',5'-trimethoxyphenyl)ethyne 
• 185698-54-8 2-[3-(tert-butyldimethylsilyloxy)-4-methoxyphenyl]-1-(3,4,5-trimethoxyphenyl)ethyne 
• 1452531-55-3 C₃₅H₅₂O₇ 
• 1452531-58-6 C₃₅H₅₀O₇ 
• 1452531-61-1 C₃₅H₄₈O₇ 

Relevant articles and documents

A novel and convenient method for the synthesis of phenstatin

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Synthesis and biological evaluation of 1‐(Diarylmethyl)‐1h‐1,2,4‐triazoles and 1‐(diarylmethyl)‐1h‐imidazoles as a novel class of anti‐mitotic agent for activity in breast cancer

We report the synthesis and biochemical evaluation of compounds that are designed as hybrids of the microtubule targeting benzophenone phenstatin and the aromatase inhibitor letrozole. A preliminary screening in estrogen receptor (ER)‐positive MCF‐7 breast cancer cells identified 5‐((2H‐1,2,3‐triazol‐1‐yl)(3,4,5‐trimethoxyphenyl)methyl)‐2‐methoxyphenol 24 as a potent antiproliferative compound with an IC50 value of 52 nM in MCF‐7 breast cancer cells (ER+/PR+) and 74 nM in triple‐negative MDA‐MB‐231 breast cancer cells. The compounds demonstrated significant G2/M phase cell cycle arrest and induction of apoptosis in the MCF‐7 cell line, inhibited tubulin polymerisation, and were selective for cancer cells when evaluated in non-tumorigenic MCF‐10A breast cells. The immunofluorescence staining of MCF‐7 cells confirmed that the compounds targeted tubulin and induced multinucleation, which is a recognised sign of mitotic catastrophe. Computational docking studies of compounds 19e, 21l, and 24 in the colchicine binding site of tubulin indicated potential binding conformations for the compounds. Compounds 19e and 21l were also shown to selectively inhibit aromatase. These compounds are promising candidates for development as antiproliferative, aromatase inhibitory, and microtubule‐disrupting agents for breast cancer.

Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands

The majority of cancers detected every year are treated with anti-cancer compounds. Unfortunately, many tumors become resistant to antineoplastic drugs. One option is to use cocktails of compounds acting on different targets to try to overcome the resista