20357-65-7Relevant articles and documents
A flexible route to bioactive 6-alkyl-α-pyrones
Qu, Yang,Kraus, George A.
supporting information, p. 892 - 893 (2017/02/18)
Both 6-chloro-α-pyrones and 3-chlorobenzopyran-1-ones react with malonates followed by a double decarboalkoxylation to give the corresponding alkyl and alkenyl products.
First total synthesis of naturally occurring (-)-nitidon and its enantiomer
Bellina, Fabio,Carpita, Adriano,Mannocci, Luca,Rossi, Renzo
, p. 2610 - 2619 (2007/10/03)
The first total synthesis of naturally occurring (-)-nitidon and its enantiomer is reported. The best of the routes investigated for preparation of these enantiomerically pure compounds involves a modification of the Cadiot-Chodkiewicz reaction and the Sharpless asymmetric epoxidation of an (E)-2-ene-4,6-diyn-1-ol as key steps and proceeds in five steps and 18% overall yield. Both enantiomers of nitidon and some related 6-(1,3-diyn-1-yl)-2H-pyran- 2-ones have been found to exhibit significant cytotoxic activity against human cancer cell lines in vitro. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004).