20358-02-5

Basic information

• Product Name: 2-AMINO-4-BROMOBENZOTHIAZOLE
• Synonyms: 2-AMINO-4-BROMOBENZOTHIAZOLE;4-Bromobenzo[d]thiazol-2-amine;2-Amino-4-bromobenzo[d]thiazole;2-BenzothiazolaMine, 4-broMo-;4-BroMo-benzothiazol-2-ylaMine;4-broMo-2-aMinobenzothiazole;2-Amino-4-aromobenzothiazole;4-Bromo-2-benzothiazolamine
• CAS NO: 20358-02-5
• Molecular Formula: C₇H₅BrN₂S
• Molecular Weight: 229.097
• Product Categories: blocks;Bromides;Thiazoles
• Mol File: 20358-02-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 182-184 °C(Solv: ethanol (64-17-5))
• Boiling Point: 366.8 °C at 760 mmHg
• Flash Point: 175.7 °C
• Appearance: /
• Density: 1.837 g/cm³
• Vapor Pressure: 1.42E-05mmHg at 25°C
• Refractive Index: 1.783
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.14±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-4-BROMOBENZOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-BROMOBENZOTHIAZOLE(20358-02-5)
• EPA Substance Registry System: 2-AMINO-4-BROMOBENZOTHIAZOLE(20358-02-5)

Safety Data

• Hazardous Substances Data: 20358-02-5(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C7H5BrN2S/c8-4-2-1-3-5-6(4)10-7(9)11-5/h1-3H,(H2,9,10)

Upstream product

• 5391-30-0 1-(2-bromophenyl)thiourea 
• 615-36-1 2-bromoaniline 
• 94718-79-3 o-bromoaniline hydrochloride 
• 333-20-0 potassium thioacyanate 
• 767-68-0 4-bromo-1,3-benzothiazole 
• 3425-46-5 potassium selenocyanate 

Downstream Products

• 1258070-68-6 C₁₆H₁₅BrN₂O₃S₂ 
• 1309261-86-6 C₂₁H₁₃BrN₄OS 
• 1309261-65-1 3-(4-bromo-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4(3H)-one 

Relevant articles and documents

Straightforward convergent access to 2-arylated polysubstituted benzothiazoles

A modular access to 2,4 disubstituted benzothiazoles has been achieved though the intermediacy of 4-bromo-2-iodobenzothiazole. The difference in reactivity of both halogens was advantageously exploited to achieve sequential Suzuki-Miyaura cross-coupling g

Chiral Benzothiazole Monofluoroborate Featuring Chiroptical and Oxygen-Sensitizing Properties: Synthesis and Photophysical Studies

Advances in personalized medicine are prompting the development of multimodal agents, that is, molecules that combine properties promoting various diagnostic and therapeutic applications. General approaches exploit chemical conjugation of therapeutic agen

SN-Donor methylthioanilines and copper(II) complexes: Synthesis, spectral properties, and in vitro antimicrobial activity

Methylthioanilines, a series of sulfur-nitrogen donor ligands substituted with OCH3, CH3, Cl, and Br, and their copper(II) complexes have been synthesized and characterized by 1H and 13C NMR, elemental analysis, FTIR, UV-Vis and EPR spectra, molar conductance, and magnetic susceptibility measurements. The NMR spectra of the ligands revealed that the para/ortho protons and para carbon were sensitive to the electronic effect of substituents. The CHNS analysis presented CuLCl2 (L = OCH3, CH3, Cl) and CuL2Cl2 (L = Br) stoichiometries for the copper complexes. FTIR spectra showed that the bidentate ligands were coordinated to the copper ion through their nitrogen and sulfur atoms. The electronic spectra have suggested square planar and octahedral geometries for these complexes. The EPR spectra demonstrated that the solid state copper(II) complexes possess dx2-y2 orbital ground state and g= > g > 2.0023 in a tetragonal environment. The compounds were evaluated for in vitro antimicrobial activity against S. aureus, B. subtilis, E. coli, and C. albicans. The copper complexes showed higher activity than the parent ligands against S. aureus and B. subtilis; the electron-donating OCH3 and CH3 derivatives were more active than the withdrawing Br- A nd Cl-substituted compounds.