203640-35-1

Basic information

• Product Name: 4-[(anilinocarbonyl)amino]benzenesulfonyl chloride
• Synonyms: 4-[(anilinocarbonyl)amino]benzenesulfonyl chloride
• CAS NO: 203640-35-1
• Molecular Weight: 310.761
• Mol File: 203640-35-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-[(anilinocarbonyl)amino]benzenesulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(anilinocarbonyl)amino]benzenesulfonyl chloride(203640-35-1)
• EPA Substance Registry System: 4-[(anilinocarbonyl)amino]benzenesulfonyl chloride(203640-35-1)

Safety Data

• Hazardous Substances Data: 203640-35-1(Hazardous Substances Data)

Upstream product

• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 24939-24-0 4-aminobenzenesulfonyl chloride 
• 103-71-9 phenyl isocyanate 
• 102-07-8 bis(diphenyl)urea 
• 6752-38-1 4-chlorosulfonylbenzene isocyanate 
• 62-53-3 aniline 

Downstream Products

• 1489080-54-7 (6R,7R)-3-[(acetyloxy)methyl]-7-[({4-[(anilinocarbonyl)amino]phenyl}sulfonyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 819060-90-7 C₂₀H₁₉N₃O₃S 
• 289638-78-4 FG 1891 
• 392691-42-8 1-[4-(4-aminomethyl-piperidine-1-sulfonyl)-phenyl]-3-phenyl-urea 
• 203640-00-0 (R)-3-(1H-Indol-3-yl)-2-[4-(3-phenyl-ureido)-benzenesulfonylamino]-propionic acid methyl ester 

Relevant articles and documents

METHODS OF INHIBITING BACTERIAL VIRULENCE AND COMPOUNDS RELATING THERETO

The present invention relates to compounds and methods for the treatment of bacterial infections. Because their mechanism of action does not involve killing of bacteria or inhibiting their growth, the potential for these compounds to induce drug resistance in bacteria is minimized. Through inhibiting bacterial virulence, the present invention provides a novel means of treating bacterial infections.

Design and synthesis of procollagen C-proteinase inhibitors

Non-peptidic inhibitors of procollagen C-proteinase (PCP) were designed from substrate leads. Compounds were optimized for potency and selectivity, with N-substituted aryl sulfonamide hydroxamates having the best combination of these properties. Compounds

Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives

Various N-sulfonylamino acid derivatives were synthesized and evaluated for their in vitro and in vivo activities to inhibit type IV collagenase (MMP-9 and MMP-2). When the amino acid residue and the sulfonamide moiety were modified, their inhibitory activities were greatly affected by the structure of the sulfonamide moiety. A series of aryl sulfonamide derivatives containing biaryl, tetrazole, amide, and triple bond were found to be potent and highly selective inhibitors of MMP-9 and MMP-2. In addition, these compounds were orally active in animal models of tumor growth and metastasis. These results revealed the potential of the N-sulfonylamino acid derivatives as a new type of candidate drug for the treatment of cancer.