20367-99-1

Basic information

• Product Name: Propanedioic acid, (acetylamino)[(4-fluoro-3-nitrophenyl)methyl]-, diethyl ester
• CAS NO: 20367-99-1
• Molecular Formula: C16H19FN2O7
• Molecular Weight: 370.334
• Mol File: 20367-99-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, (acetylamino)[(4-fluoro-3-nitrophenyl)methyl]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, (acetylamino)[(4-fluoro-3-nitrophenyl)methyl]-, diethyl ester(20367-99-1)
• EPA Substance Registry System: Propanedioic acid, (acetylamino)[(4-fluoro-3-nitrophenyl)methyl]-, diethyl ester(20367-99-1)

Safety Data

• Hazardous Substances Data: 20367-99-1(Hazardous Substances Data)

Upstream product

• 221123-51-9 4-fluoro-3-nitrobenzyl iodide 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 20274-70-8 4-(chloromethyl)-1-fluoro-2-nitrobenzene 
• 20274-69-5 (4-fluoro-3-nitrophenyl)methanol 
• 453-71-4 3-nitro-4-fluorobenzoic acid 
• 15017-52-4 4-(bromomethyl)-1-fluoro-2-nitrobenzene 

Downstream Products

• 193073-45-9 methyl 2-((tert-butoxycarbonyl)amino)-3-(4-fluoro-3-nitrophenyl)propanoate 
• 188624-30-8 (R)-N-trifluoroacetyl-4-fluoro-3-nitrophenylalanine methyl ester 
• 188624-24-0 (RS)-N-trifluoroacetyl-4-fluoro-3-nitrophenylalanine methyl ester 
• 188624-28-4 (S)-N-trifluoroacetyl-4-fluoro-3-nitrophenylalanine 
• 178744-39-3 L-4-fluoro-3-nitrophenylalanine methyl ester 
• 173775-54-7 (R)-N-(tert-butoxycarbonyl)-4-fluoro-3-nitrophenylalanine 
• 707540-24-7 4-fluoro-3-nitrophenylalanine 

Relevant articles and documents

Ultrafast Photoinduced Electron Transfer in Green Fluorescent Protein Bearing a Genetically Encoded Electron Acceptor

Electron transfer (ET) is widely used for driving the processes that underlie the chemistry of life. However, our abilities to probe electron transfer mechanisms in proteins and design redox enzymes are limited, due to the lack of methods to site-specific

Quantitative insight into the design of compounds recognized by the L-type amino acid transporter 1 (LAT1)

L-Type amino acid transporter 1 (LAT1) is a transmembrane protein expressed abundantly at the blood-brain barrier (BBB), where it ensures the transport of hydrophobic acids from the blood to the brain. Due to its unique substrate specificity and high expression at the BBB, LAT1 is an intriguing target for carrier- mediated transport of drugs into the brain. In this study, a comparative molecular field analysis (CoMFA) model with considerable statistical quality (Q2=0.53, R2=0.75, Q2 SE=0.77, R2 SE=0.57) and good external predictivity (CCC=0.91) was generated. The model was used to guide the synthesis of eight new prodrugs whose affinity for LAT1 was tested by using an in situ rat brain perfusion technique. This resulted in the creation of a novel LAT1 prodrug with l-tryptophan as the promoiety; it also provided a better understanding of the molecular features of LAT1-targeted high-affinity prodrugs, as well as their promoiety and parent drug. The results obtained will be beneficial in the rational design of novel LAT1-binding prodrugs and other compounds that bind to LAT1.

Chemoenzymatic synthesis of enantiomerically pure 4-fluoro-3-nitro and 3-fluoro-4-nitro phenylallanine

Both antipodes of enantiomerically pure 4-fluoro-3-nitrophenylalanine and 3-fluoro-4-nitrophenylalanine were obtained from their corresponding racemates via enzymatic resolution.