20368-13-2

Basic information

• Product Name: 1-(piperidin-1-yl)nonan-1-one
• CAS NO: 20368-13-2
• Molecular Formula: C₁₄H₂₇NO
• Molecular Weight: 225.3703
• Mol File: 20368-13-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 346.2°C at 760 mmHg
• Flash Point: 142.6°C
• Density: 0.922g/cm³
• Vapor Pressure: 5.84E-05mmHg at 25°C
• Refractive Index: 1.47
• CAS DataBase Reference: 1-(piperidin-1-yl)nonan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(piperidin-1-yl)nonan-1-one(20368-13-2)
• EPA Substance Registry System: 1-(piperidin-1-yl)nonan-1-one(20368-13-2)

Safety Data

• Hazardous Substances Data: 20368-13-2(Hazardous Substances Data)

Usage

Chemical class

Ketones

Explanation

1-(piperidin-1-yl)nonan-1-one is an organic compound characterized by a carbonyl group (C=O) bonded to two carbon atoms.

Explanation

The compound consists of a nonane (9-carbon) chain with a piperidine ring (a saturated heterocyclic amine) attached to the first carbon.

Explanation

1-(piperidin-1-yl)nonan-1-one is commonly used as a starting material for the synthesis of various pharmaceuticals and organic compounds.

Explanation

The compound has been found to exhibit biological activities, such as inhibiting the enzyme FAAH, which plays a role in the endocannabinoid system.

Explanation

Due to its potential applications in drug development and medicinal chemistry, 1-(piperidin-1-yl)nonan-1-one is of interest to researchers and chemists.

Structure

Nonane chain with a piperidine ring attached at the first carbon

Precursor in synthesis

Pharmaceutical and organic compounds

Biological activity

Potential inhibitor of fatty acid amide hydrolase (FAAH)

Interest to researchers

Drug development and medicinal chemistry

Upstream product

• 110-89-4 piperidine 
• 112-05-0 nonanoic acid 
• 74472-23-4 3-nonanoyl-1,3-thiazolidine-2-thione 
• 135676-75-4 1,5-Dinonanoyl-[1,3,5]triazinane-2,4-dione 
• 111-66-0 oct-1-ene 
• 201230-82-2 carbon monoxide 
• 764-85-2 Nonanoyl chloride 
• 6091-44-7 piperidine hydrochloride 
• 215667-89-3 3-iodo-1-piperidino-1-propanone 
• 90154-52-2 3-bromo-1-(piperidin-1-yl)propan-1-one 

Relevant articles and documents

Visible-Light-Induced Nickel-Catalyzed Cross-Coupling with Alkylzirconocenes from Unactivated Alkenes

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Chemoselective Intermolecular Cross-Enolate-Type Coupling of Amides

A new approach for the synthesis of 1,4-dicarbonyl compounds is reported. Chemoselective activation of amide carbonyl functionality and subsequent umpolung via N-oxide addition generates an electrophilic enolonium species that can be coupled with a wide range of nucleophilic enolates. The method conveys broad functional group tolerance on both components, does not suffer from formation of homocoupling byproducts and avoids the use of transition metal catalysts.

Rh(I)-Catalyzed Hydroamidation of Olefins via Selective Activation of N-H Bonds in Aliphatic Amines

Hydroamidation of olefins constitutes an ideal, atom-efficient method to prepare carboxylic amides from easily available olefins, CO, and amines. So far, aliphatic amines are not suitable for these transformations. Here, we present a ligand- and additive-free Rh(I) catalyst as solution to this problem. Various amides are obtained in good yields and excellent regioselectivities. Notably, chemoselective amidation of aliphatic amines takes place in the presence of aromatic amines and alcohols. Mechanistic studies reveal the presence of Rh-acyl species as crucial intermediates for the selectivity and rate-limiting step in the proposed Rh(I)-catalytic cycle. (Chemical Formula Presented).