203794-33-6

Basic information

• Product Name: 5,6-dichloro-3-nitropyridin-2-aMine
• Synonyms: 5,6-dichloro-3-nitropyridin-2-aMine;5,6-dichloro-2-amino-3-nitropyridine;5,6-Dichloro-3-nitro-2-pyridinamine
• CAS NO: 203794-33-6
• Molecular Formula: C₅H₃Cl₂N₃O₂
• Molecular Weight: 208.00222
• Mol File: 203794-33-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 347.1±37.0 °C(Predicted)
• Appearance: /
• Density: 1.723±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: -3.87±0.50(Predicted)
• CAS DataBase Reference: 5,6-dichloro-3-nitropyridin-2-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-dichloro-3-nitropyridin-2-aMine(203794-33-6)
• EPA Substance Registry System: 5,6-dichloro-3-nitropyridin-2-aMine(203794-33-6)

Safety Data

• Hazardous Substances Data: 203794-33-6(Hazardous Substances Data)

Usage

General Description

5,6-dichloro-3-nitropyridin-2-amine is a chemical compound with the molecular formula C5H3Cl2N3O2. It is an aromatic amine that contains two chlorine atoms and one nitro group attached to a pyridine ring. 5,6-dichloro-3-nitropyridin-2-aMine is used in the synthesis of pharmaceuticals and agrochemicals. It also has potential applications as a building block in organic chemistry research. 5,6-dichloro-3-nitropyridin-2-amine is classified as a hazardous substance and should be handled with care due to its toxic and potentially harmful properties.

Upstream product

• 45644-21-1 6-chloropyridin-2-amine 

Downstream Products

• 97941-89-4 5,6-dichloropyridine-2,3-diamine 
• 1364524-13-9 (4-(6-amino-3-chloro-5-nitropyridin-2-yl)piperazin-1-yl)(3-(2-methoxyphenyl)-5-methylisoxazol-4-yl)methanone 
• 1394371-58-4 (2R,3S,5R)-5-((5-([1,1'-biphenyl]-4-yl)-6-chloro-1H-imidazo[4,5-b]pyridin-2-yl)oxy)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-ol 
• 1394371-76-6 (3R,3aR,6R,6aR)-6-[[6-chloro-5-[4-(4-pyrazol-1-ylphenyl)phenyl]-1H-imidazo[4,5-b]pyridin-2-yl]oxy]-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol 
• 1394371-78-8 (3R,3aR,6R,6aR)-6-[[6-chloro-5-[4-[4-(1-methylimidazol-2-yl)phenyl]phenyl]-1H-imidazo[4,5-b]pyridin-2-yl]oxy]-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol 
• 1394372-10-1 C₂₆H₂₁ClN₆O₄ 
• 1394372-13-4 (3R,3aR,6R,6aR)-6-((5-(4'-(1H-1,2,4-triazol-1-yl)-[1,1'-biphenyl]-4-yl)-6-chloro-1H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol 
• 1394372-49-6 (3R,3aR,6R,6aR)-6-[[6-chloro-5-[4-(5-pyrazol-1-yl-2-pyridyl)phenyl]-1H-imidazo[4,5-b]pyridin-2-yl]oxy]-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol 
• 1394372-57-6 (3R,3aR,6R,6aR)-6-[[6-chloro-5-[4-[5-[4-(2-hydroxy-2-methyl-propyl)pyrazol-1-yl]-2-pyridyl]phenyl]-1H-imidazo[4,5-b]pyridin-2-yl]oxy]-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol 
• 1394372-59-8 (3aR,6R,6aR)-6-[[6-chloro-5-[4-[6-(1,2,4-triazol-1-yl)-3-pyridyl]phenyl]-1H-imidazo[4,5-b]pyridin-2-yl]oxy]-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol 
• 1394372-67-8 (3R,3aR,6R,6aR)-6-[[6-chloro-5-[4-[4-(1H-tetrazol-5-yl)phenyl]phenyl]-1H-imidazo[4,5-b]pyridin-2-yl]oxy]-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol 
• 1394372-84-9 2-[[(3R,3aR,6S,6aS)-6-fluoro-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]oxy]-6-chloro-5-(4-phenylphenyl)-1H-imidazo[4,5-b]pyridine 
• 1394372-86-1 (3R,3aR,6R,6aR)-6-((6-chloro-5-(4-(piperidin-4-ylethynyl)phenyl)-1H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol 
• 1394373-31-9 methyl 5-[(6-chloro-5-iodo-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazo[4,5-b]pyridin-2-yl)oxy]-2-methylbenzoate 

Relevant articles and documents

Design, synthesis and anti-HBV activity evaluation of new substituted imidazo[4,5-b]pyridines

The design and synthesis of a number of new imidazo[4,5-b]pyridines is described. The heterocyclic scaffold possesses 6-chloro- or 5,6-dichloro-substitution and bears various 2-alkylamino-methyl or ethyl groups. The corresponding N1 and N3-tosylates are also presented. The anti-HBV activity of the compounds was evaluated in HBV infectious system at the level of HBV rcDNA secretion and CC50, EC50 and selectivity index values were determined. The tosylates showed low antiviral potency and relatively high cytotoxicity, on the contrary, a number of 2,5 and/or-6-substituted imidazopyridines, mainly those belonging to the 6-chloroimidazo[4,5-b]pyridine series, were endowed with a very interesting profile and were further investigated. The most promising among them, along with the reduction of the secreted HBV rcDNA, also caused a reduction in HBV cccDNA and pgRNA levels, with a concomitant accumulation of the intracellular encapsidated rcDNA. Surprisingly, the most active 2-diethylaminoethyl-substituted derivative (21d), was highly competitive to interferon.