2038-40-6

Basic information

• Product Name: 1-methyl-9-azabicyclo[3.3.1]nonan-3-ol
• Synonyms: 1-Methyl-9-azabicyclo[3.3.1]nonan-3-ol
• CAS NO: 2038-40-6
• Molecular Formula: C₉H₁₇NO
• Molecular Weight: 155.2374
• Mol File: 2038-40-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 247°C at 760 mmHg
• Flash Point: 96.3°C
• Density: 1.045g/cm³
• Vapor Pressure: 0.00431mmHg at 25°C
• Refractive Index: 1.511
• CAS DataBase Reference: 1-methyl-9-azabicyclo[3.3.1]nonan-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-9-azabicyclo[3.3.1]nonan-3-ol(2038-40-6)
• EPA Substance Registry System: 1-methyl-9-azabicyclo[3.3.1]nonan-3-ol(2038-40-6)

Safety Data

• Hazardous Substances Data: 2038-40-6(Hazardous Substances Data)

Upstream product

• 552-70-5 pseudopelletierine 
• 552-70-5 granatan-3-one 
• 32752-52-6 1-(N-methyl)-1,5-pentanediamine 
• 64-17-5 ethanol 

Downstream Products

• 6376-00-7 exo-9-methyl-9-azabicyclo[3.3.1]nonan-3-ol 
• 504-12-1 exo-9-azabicyclo[3.3.1]nonan-3-ol 
• 552-70-5 pseudopelletierine 
• 854733-35-0 3endo-hydroxy-9-aza-bicyclo[3.3.1]nonane-9-carboxylic acid 
• 22143-89-1 (+/-)-Tropoyl granatan-3a-ol 

Relevant articles and documents

Substrate Conformation Correlates with the Outcome of Hyoscyamine 6β-Hydroxylase Catalyzed Oxidation Reactions

Hyoscyamine 6β-hydroxylase (H6H) is an α-ketoglutarate dependent mononuclear nonheme iron enzyme that catalyzes C6-hydroxylation of hyoscyamine and oxidative cyclization of the resulting product to give the oxirane natural product scopolamine. Herein, the chemistry of H6H is investigated using hyoscyamine derivatives with modifications at the C6 or C7 position as well as substrate analogues possessing a 9-azabicyclo[3.3.1]nonane core. Results indicate that hydroxyl rebound is unlikely to take place during the cyclization reaction and that the hydroxylase versus oxidative cyclase activity of H6H is correlated with the presence of an exo-hydroxy group having syn-periplanar geometry with respect to the adjacent H atom to be abstracted.

Tetraaza-cyclopenta[a]indenyl derivatives

The present invention provides compounds of Formula (I) as M1 receptor positive allosteric modulators for the treatment of diseases mediated by the muscarinic M1 mediator.

FUSED BICYCLOHETEROCYCLE SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES

The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.