203912-55-4

Basic information

• Product Name: Benzenemethanol, a-ethyl-3,5-dimethoxy-
• CAS NO: 203912-55-4
• Molecular Formula: C11H16O3
• Molecular Weight: 196.246
• Mol File: 203912-55-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, a-ethyl-3,5-dimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-ethyl-3,5-dimethoxy-(203912-55-4)
• EPA Substance Registry System: Benzenemethanol, a-ethyl-3,5-dimethoxy-(203912-55-4)

Safety Data

• Hazardous Substances Data: 203912-55-4(Hazardous Substances Data)

Upstream product

• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 2386-64-3 ethylmagnesium chloride 
• 925-90-6 ethylmagnesium bromide 
• 17213-57-9 3,5-dimethoxybenzoyl chloride 
• 1132-21-4 3,5-dimethoxybenzoic acid 
• 557-20-0 diethylzinc 
• 74-96-4 ethyl bromide 
• 10467-10-4 ethylmagnesium iodide 

Downstream Products

• 41395-10-2 1,3-dimethoxy-5-propylbenzene 
• 146205-98-3 (E)-1,3-dimethoxy-5-(prop-1-en-1-yl)benzene 
• 203912-56-5 2,6-dimethoxy-4-n-propylphenylacetaldehyde 
• 203912-57-6 (E)-ethyl 4-(2,6-dimethoxy-4-propylphenyl)-2-methylcrotonate 
• 500-49-2 5-propyl-1,3-benzenediol 
• 55136-70-4 3-methoxy-5-propylphenol 
• 41497-31-8 3,5-dimethoxyphenyl ethyl ketone 

Relevant articles and documents

STRUCTURE-ACTIVITY RELATIONSHIPS OF PHENYLPROPANOIDS AS GROWTH INHIBITORS OF THE GREEN ALGA SELENASTRUM CAPRICORNUTUM

Twenty-seven commercial or synthetic phenylpropanoids have been tested in broth against the unicellular alga Selenastrum capricornutum.The antialgal activity seems to be linked to the number as well as to the position of the methoxyl group in the molecule.A slight effect of the side chain substitution was also observed. Key Word Index - Selenastrum capricornutum; allelochemicals; phenylpropanoids.

Euodenine A: A small-molecule agonist of human TLR4

A small-molecule natural product, euodenine A (1), was identified as an agonist of the human TLR4 receptor. Euodenine A was isolated from the leaves of Euodia asteridula (Rutaceae) found in Papua New Guinea and has an unusual U-shaped structure. It was synthesized along with a series of analogues that exhibit potent and selective agonism of the TLR4 receptor. SAR development around the cyclobutane ring resulted in a 10-fold increase in potency. The natural product demonstrated an extracellular site of action, which requires the extracellular domain of TLR4 to stimulate a NF-κB reporter response. 1 is a human-selective agonist that is CD14-independent, and it requires both TLR4 and MD-2 for full efficacy. Testing for immunomodulation in PBMC cells shows the induction of the cytokines IL-8, IL-10, TNF-α, and IL-12p40 as well as suppression of IL-5 from activated PBMCs, indicating that compounds like 1 could modulate the Th2 immune response without causing lung damage.

QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR

This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to quinoline-derived amides that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.