203922-20-7

Basic information

• Product Name: 1-(2-chloroethoxy)-4-fluoro-3-aminobenzene
• Synonyms: 1-(2-chloroethoxy)-4-fluoro-3-aminobenzene
• CAS NO: 203922-20-7
• Molecular Weight: 189.617
• Mol File: 203922-20-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(2-chloroethoxy)-4-fluoro-3-aminobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloroethoxy)-4-fluoro-3-aminobenzene(203922-20-7)
• EPA Substance Registry System: 1-(2-chloroethoxy)-4-fluoro-3-aminobenzene(203922-20-7)

Safety Data

• Hazardous Substances Data: 203922-20-7(Hazardous Substances Data)

Upstream product

• 203922-19-4 1-(2-Chloroethoxy)-2.6-dibromo-4-fluoro-3-nitrobenzene 
• 371-41-5 4-Fluorophenol 
• 344-20-7 2,6-dibromo-4-fluorophenol 
• 203922-16-1 1,3-dibromo-2-(2-chloroethoxy)-5-fluorobenzene 

Downstream Products

• 203921-01-1 4-(2-benzylamino-ethoxy)-7-fluoro-1,3-dihydro-indol-2-one 
• 203922-23-0 4-(2-benzylaminoethoxy)-7-fluoro-3-thiomethyl-1,3-dihydroindol-2-one 
• 203922-24-1 4-(2-cyclohexylmethylaminoethoxy)-7-fluoro-3-thiomethyl-1,3-dihydroindol-2-one 
• 203922-25-2 4-<2-(biphenyl-3-ylmethylamino)ethoxy>-7-fluoro-3-thiomethyl-1,3-dihydroindol-2-one 

Relevant articles and documents

4-AMINOETHOXY INDOLONE DERIVATIVES

A compound of formula (I) in which Y is hydrogen, halogen or lower alkoxy; R1 is hydrogen, lower alkyl or aryl(lower)alkyl; R2 is hydrogen, lower alkyl or -(CH2)nXpAr, where X is oxygen or carbonyl; Ar is cycloalkyl, aryl or arylaryl, oxindolyl, benzimidazolyl, indolyl, 2-oxobenzimidazolyl or 2-thioxobenzimidazolyl; or R1 and R2, taken together with the nitrogen atom to which they are attached, complete a 3,4-dihydro-1H-isoquinolinyl or 1,3-dihydro-isoindolyl; n is one of the integers 1,2,3,4,5 or 6; p is one of the integers 0 or 1; or a pharmaceutically acceptable salt thereof are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analogous drugs.

New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates

Described in this report is a systematic study which led to the identification of two new dopamine D2 partial agonists (5 and 17). Phenols 5 and 17 represent prototypes of two new classes of D2 partial agonist as well as templates for the future design of novel dopaminergic agents.