20395-87-3 Usage
Description
2-(Benzyloxycarbonylamino)butyric acid is a chemical compound that serves as a key intermediate in the synthesis of peptides and other complex organic molecules. It is a derivative of butyric acid, featuring a benzyl group and a carbonylamino functional group. 2-(BENZYLOXYCARBONYLAMINO)BUTYRIC ACID is known for its role as a protecting group in peptide synthesis, where it temporarily shields certain functional groups on amino acids to regulate the sequence of reactions. Additionally, it functions as a precursor in the production of pharmaceuticals and other organic compounds, highlighting its significance in the realm of organic chemistry.
Uses
Used in Pharmaceutical Industry:
2-(Benzyloxycarbonylamino)butyric acid is used as a precursor for the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its ability to serve as a building block in the creation of complex organic compounds makes it invaluable in the advancement of medicinal chemistry.
Used in Organic Chemistry Research:
In the field of organic chemistry, 2-(Benzyloxycarbonylamino)butyric acid is utilized as a protecting group in peptide synthesis. It is employed to temporarily block specific functional groups on amino acids, allowing for controlled and selective reactions to occur. This selective protection is crucial for the successful synthesis of complex peptide sequences and the development of novel bioactive molecules.
Used in Peptide Synthesis:
2-(Benzyloxycarbonylamino)butyric acid is used as a protecting group in the synthesis of peptides, ensuring that the desired sequence of amino acids is achieved without unwanted side reactions. This selective protection is essential for the successful assembly of peptides with specific biological activities and properties.
Overall, 2-(Benzyloxycarbonylamino)butyric acid plays a multifaceted role in various applications across the pharmaceutical and chemical industries, from the synthesis of complex molecules to the development of innovative drug delivery systems and therapeutic agents. Its versatility and importance in organic chemistry make it a valuable compound for researchers and chemists alike.
Check Digit Verification of cas no
The CAS Registry Mumber 20395-87-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,3,9 and 5 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 20395-87:
(7*2)+(6*0)+(5*3)+(4*9)+(3*5)+(2*8)+(1*7)=103
103 % 10 = 3
So 20395-87-3 is a valid CAS Registry Number.
20395-87-3Relevant articles and documents
Identification, characterization, synthesis and strategy for minimization of potential impurities observed in the synthesis of brivaracetam
Liao, Shouzhu,Chen, Hongjun,Wang, Guifei,Wu, Shuming,Yang, Zaiyou,Luo, Weihe,Liu, Zhuanfeng,Gao, Xun,Qin, Junhai,Li, Chuan-hua,Wang, Zhongqing
, (2020/05/25)
A first systematic impurity profile research concerning nine observed and potential process related impurities of antiepileptic drug brivaracetam is reported. Among which three (impurity G/H/I) have not been discovered or reported before, these nine impurities were monitored by HPLC, and their structures were identified on the basis of MS and NMR spectroscopy. In addition to the formation, synthesis, and characterization, strategies for minimizing these impurities to the levels accepted by ICH are also described in this report.
Assay and inhibition of diacylglycerol lipase activity
Johnston, Meghan,Bhatt, Shachi R.,Sikka, Surina,Mercier, Richard W.,West, Jay M.,Makriyannis, Alexandros,Gatley, S. John,Duclos Jr., Richard I.
scheme or table, p. 4585 - 4592 (2012/08/08)
A series of N-formyl-α-amino acid esters of β-lactone derivatives structurally related to tetrahydrolipstatin (THL) and O-3841 were synthesized that inhibit human and murine diacylglycerol lipase (DAGL) activities. New ether lipid reporter compounds were developed for an in vitro assay to efficiently screen inhibitors of 1,2-diacyl-sn-glycerol hydrolysis and related lipase activities using fluorescence resonance energy transfer (FRET). A standardized thin layer chromatography (TLC) radioassay of diacylglycerol lipase activity utilizing the labeled endogenous substrate [1″- 14C]1-stearoyl-2-arachidonoyl-sn-glycerol with phosphorimaging detection was used to quantify inhibition by following formation of the initial product [1″-14C]2-arachidonoylglycerol and further hydrolysis under the assay conditions to [1-14C]arachidonic acid.
Resolution of non-protein amino acids via Carica papaya lipase-catalyzed enantioselective transesterification
Miyazawa, Toshifumi,Onishi, Kazuki,Murashima, Takashi,Yamada, Takashi,Tsai, Shau-Wei
, p. 2569 - 2573 (2007/10/03)
Carica papaya lipase-catalyzed transesterification of the 2,2,2-trifluoroethyl esters of N-benzyloxycarbonylated dl-amino acids carrying aliphatic side chains proceeded smoothly and, in almost all the cases, enantiospecifically (E = >200), affording the l-methyl esters and leaving the d-trifluoroethyl esters intact.