2040-86-0

Basic information

• Product Name: 2-Bromo-6-iodophenol
• Synonyms: 2-Bromo-6-iodophenol
• CAS NO: 2040-86-0
• Molecular Formula: C₆H₄BrIO
• Molecular Weight: 298.90383
• Mol File: 2040-86-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 63 °C
• Boiling Point: 214.4±25.0 °C(Predicted)
• Appearance: /
• Density: 2.369±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 6.98±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-6-iodophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-6-iodophenol(2040-86-0)
• EPA Substance Registry System: 2-Bromo-6-iodophenol(2040-86-0)

Safety Data

• Hazardous Substances Data: 2040-86-0(Hazardous Substances Data)

Usage

General Description

2-Bromo-6-iodophenol is a chemical compound with the molecular formula C6H4BrIO. It is a synthetic intermediate that is commonly used in organic synthesis and pharmaceutical research. 2-Bromo-6-iodophenol is a derivative of phenol and contains bromine and iodine atoms attached to the aromatic ring. 2-Bromo-6-iodophenol is known for its ability to undergo various chemical reactions, making it valuable in the production of pharmaceuticals, agrochemicals, and other fine chemicals. It is also used as a building block in the synthesis of more complex organic molecules and can be found in research laboratories and industrial settings.

Upstream product

• 533-58-4 2-Iodophenol 
• 899427-32-8 2-bromo-6-iodophenyl isopropylcarbamate 
• 899427-29-3 2-bromo-6-(trimethylsilyl)phenyl isopropylcarbamate 
• 417698-17-0 O-2-trimethylsilylphenyl N-isopropylcarbamate 
• 95-56-7 2-hydroxybromobenzene 
• 7305-04-6 o-bromophenyl N,N-dimethylcarbamate 

Downstream Products

• 918304-56-0 (Z)-2-[2-benzyloxy-5-((S)-2-dibenzylamino-2-methoxycarbonyl-ethyl)-phenyl]-but-2-enoic acid 2-bromo-6-iodo-phenyl ester 

Relevant articles and documents

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Pd(II) catalyzed ortho C-H iodination of phenylcarbamates at room temperature using cyclic hypervalent iodine reagents

A novel approach to access ortho iodinated phenols using cyclic hypervalent iodine reagents through palladium(II) catalyzed C-H activation has been developed through weak coordination. The reaction showed excellent regioselectivity, reactivity and good functional group tolerance. A unique mechanism was proposed.

Synthesis of halogenated phenols by directed ortho-lithiation and ipso-iododesilylation reactions of O-aryl N-isopropylcarbamates

The regioselective synthesis of halogenated phenols via directed ortho-lithiation reactions of in situ N-silylated O-aryl N-isopropylcarbamates is reported. This protocol is complemented by ipso-iododesilylation reactions of C-silylated carbamates and iodine-magnesium exchange reactions, which are facilitated by the adjacent carbamoyl group. These methods provide an entry into a series of o-fluoro-, o-iodo-, and o,o′-diiodophenols in high yields which are otherwise difficult to obtain. Georg Thieme Verlag Stuttgart.