204062-61-3

Basic information

• Product Name: 4-chloro-2-methyl-8-(2,4,6-trimethyl-phenyl)-quinoline
• Synonyms: 4-chloro-2-methyl-8-(2,4,6-trimethyl-phenyl)-quinoline
• CAS NO: 204062-61-3
• Molecular Weight: 295.812
• Mol File: 204062-61-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-chloro-2-methyl-8-(2,4,6-trimethyl-phenyl)-quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2-methyl-8-(2,4,6-trimethyl-phenyl)-quinoline(204062-61-3)
• EPA Substance Registry System: 4-chloro-2-methyl-8-(2,4,6-trimethyl-phenyl)-quinoline(204062-61-3)

Safety Data

• Hazardous Substances Data: 204062-61-3(Hazardous Substances Data)

Upstream product

• 1201-07-6 2-methyl-4-chloro-8-bromo-quinoline 
• 5980-97-2 mesitylboronic acid 
• 25627-20-7 2′,4′,6′-trimethyl-[1,1′-biphenyl]-2-amine 
• 204062-60-2 2-methyl-8-(2,4,6-trimethyl-phenyl)-quinolin-4-ol 

Relevant articles and documents

Synthesis and SAR of 8-arylquinolines as potent corticotropin-releasing factor1 (CRF1) receptor antagonists

A series of 4-substituted 8-aryl-2-methylquinolines 4 was designed and synthesized as highly potent antagonists for the human CRF1 receptor. This series of compounds displayed parallel SAR to other bicyclic systems such as pyrazolo[1,5-a]pyrimidines, with several compounds possessing low nanomolar binding affinity. In addition to the high potency, the basicity of this 4-aminoquinoline core may offer CRF1 antagonists with lower lipophilicity.