204191-43-5Relevant articles and documents
Spectroscopic Characterization of a Reactive [Cu2(μ-OH)2]2+ Intermediate in Cu/TEMPO Catalyzed Aerobic Alcohol Oxidation Reaction
Warm, Katrin,Tripodi, Guilherme,Andris, Erik,Mebs, Stefan,Kuhlmann, Uwe,Dau, Holger,Hildebrandt, Peter,Roithová, Jana,Ray, Kallol
supporting information, p. 23018 - 23024 (2021/09/09)
CuI/TEMPO (TEMPO=2,2,6,6-tetramethylpiperidinyloxyl) catalyst systems are versatile catalysts for aerobic alcohol oxidation reactions to selectively yield aldehydes. However, several aspects of the mechanism are yet unresolved, mainly because o
Development of a commercial process for (S)-β-phenylalanine (1)
Grayson, J. Ian,Roos, Juergen,Osswald, Steffen
scheme or table, p. 1201 - 1206 (2011/12/16)
The development of a commercial manufacturing route for (S)-β-phenylalanine 8, a key pharmaceutical building block, is described. The different approaches which were investigated, based on catalytic asymmetric hydrogenation of enamide intermediates and on biocatalysis using acylase and lipase hydrolyses, are compared. The lipase resolution route was chosen for scale-up, and the final two-step process, based on readily available raw materials, is shown to be robust at full manufacturing scale
A new synthesis of β-amino acids by use of ketene diethyl acetal as enolate equivalent
Rossen, Kai,Jakubec, Pavol,Kiesel, Michael,Janik, Matthias
, p. 1819 - 1821 (2007/10/03)
Reaction of phenylsulfonyl formamides, readily available in a single step from an aromatic aldehyde and sodium phenylsulfinate, with ketene diethyl acetal under basic conditions gives N-formyl β-amino acid esters in good yield, which can be kinetically resolved with a lipase.