204326-27-2

Basic information

• Product Name: 1-((2R,4R,5R)-5-{2-[(1,1-Diethoxy-ethyl)-phenyl-phosphinoyl]-ethyl}-4-hydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
• CAS NO: 204326-27-2
• Molecular Weight: 480.498
• Mol File: 204326-27-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-((2R,4R,5R)-5-{2-[(1,1-Diethoxy-ethyl)-phenyl-phosphinoyl]-ethyl}-4-hydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((2R,4R,5R)-5-{2-[(1,1-Diethoxy-ethyl)-phenyl-phosphinoyl]-ethyl}-4-hydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione(204326-27-2)
• EPA Substance Registry System: 1-((2R,4R,5R)-5-{2-[(1,1-Diethoxy-ethyl)-phenyl-phosphinoyl]-ethyl}-4-hydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione(204326-27-2)

Safety Data

• Hazardous Substances Data: 204326-27-2(Hazardous Substances Data)

Upstream product

• 7481-90-5 3',4'-anhydrothymidine 
• 167370-02-7 [(1,1-Diethoxy-ethyl)-methyl-phosphinoyl]-benzene 
• 19315-13-0 methyl(phenyl)phosphineoxide 
• 172487-18-2 ethyl Phenylphosphinate 

Downstream Products

• 204326-28-3 1-[(2R,4R,5R)-4-Hydroxy-5-(2-phenylphosphinoyl-ethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 

Relevant articles and documents

The utilization of secondary phosphine oxide synthons for the preparation of novel tertiary phosphine oxide modified DNA

Novel tertiary phosphine oxides are described which act as masked secondary phosphine oxides. The protection of the reactive P-H bond allows generation of a carbanion alpha to phosphorus and subsequent alkylation with an oxetane. The free P-H can then be liberated with anhydrous acid. This functionality can then be further alkylated to generate novel tertiary phosphine oxide backbone modified DNA.