20434-78-0

Basic information

• Product Name: 5-chloro-3-phenylbenzo[d]isothiazole 1,1-dioxide
• Synonyms: 5-chloro-3-phenylbenzo[d]isothiazole 1,1-dioxide
• CAS NO: 20434-78-0
• Molecular Weight: 277.731
• Mol File: 20434-78-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-chloro-3-phenylbenzo[d]isothiazole 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-3-phenylbenzo[d]isothiazole 1,1-dioxide(20434-78-0)
• EPA Substance Registry System: 5-chloro-3-phenylbenzo[d]isothiazole 1,1-dioxide(20434-78-0)

Safety Data

• Hazardous Substances Data: 20434-78-0(Hazardous Substances Data)

Upstream product

• 122685-91-0 4-chloro-N,N-diphenylbenzenesulfonamide 
• 100-47-0 benzonitrile 
• 98-64-6 4-Chlorobenzenesulfonamide 
• 100-52-7 benzaldehyde 
• 14067-98-2 N-[(4-chlorophenyl)sulfonyl]benzamide 

Downstream Products

• 20434-79-1 (±)-5-chloro-3-phenyl-1,2-benzisothiazoline 1,1-dioxide 

Relevant articles and documents

Palladium-Catalyzed ortho-Benzoylation of Sulfonamides through C?H Activation: Expedient Synthesis of Cyclic N-Sulfonyl Ketimines

The ortho-carbonylation of sulfonylarenes by non-hazardous aryl aldehydes as a carbonyl precursor was reported. In this method, the sulfonamide group serves as a directing group for C?H activation in the presence of a Pd catalyst under ligand-free conditions. The scope of this strategy has been extended to the one-pot two-step synthesis of cyclic N-sulfonyl ketimines under mild reaction conditions. Our approach could be considered as an alternative by circumventing the use of highly reactive organolithium or Grignard reagents to access a wide range of biologically potent cyclic N-sulfonyl ketimines. (Figure presented.).